Personal Information

Dr. Devesh Sawant

Assistant Professor

Ph. D. at Central Drug Research Institute, Lucknow

dms@curaj.ac.in

  • Synthetic Organic Chemistry
  • Catalysis
  • RNA Folding
  • Design of Radionucleid Ligands

Semester

Course Title and Code

Credits

Class

Topics

First

Modern Pharmaceutical Analytical Techniques

MPC101T and MPH101T

4

M. Pharm (Pharmaceutical chemistry,Pharmaceutics)

IR, NMR, MS

Advanced Organic Chemistry

MPC102T

4

M. Pharm (Pharmaceutical chemistry)

Basics of Organic Reactions(Organic Intermediates, Reaction Mechnism, SN1/SN2, Elimination, Rearrangement), name reactions, Synthetic Reagents, Protecting groups, Heterocyclic Chemistry, Retrosynthesis

CHEMISTRY OF NATURAL PRODUCTS

MPC 104T

4

M. Pharm (Pharmaceutical chemistry)

Structural Characterization of Natural Compounds

PHARMACEUTICAL CHEMISTRY PRACTICAL - I

MPC 105P)

4

M. Pharm (Pharmaceutical chemistry)

Purification of organic solvents, column chromatography, Synthesis involving Name Rections:  Claisen-schimidt reaction, Benzyllic acid rearrangement, Beckmann rearrangement,  Hoffmann rearrangement, Mannich reaction

Second

ADVANCED SPECTRAL ANALYSIS MPC 201T

4

M. Pharm (Pharmaceutical chemistry)

UV< IR spectroscopy, NMR Spectroscopy, Mass Spectroscopy

ADVANCED ORGANIC CHEMISTRY - II MPC 202T

4

M. Pharm (Pharmaceutical chemistry)

Green Chemistry, Chemistry of peptides, Photochemical Reactions, Catalysis, Stereochemistry & Asymmetric Synthesis

PHARMACEUTICAL PROCESS CHEMISTRY

MPC 204T

4

M. Pharm (Pharmaceutical chemistry)

Process chemistry, Unit operations, Unit Processes – I and II

PHARMACEUTICAL CHEMISTRY PRACTICALS – II

MPC 205P

4

M. Pharm (Pharmaceutical chemistry)

Synthesis of Organic Compounds: Oxidation,  Reduction/hydrogenation, Nitration, Preparation of 4-chlorobenzhydrylpiperazine,  4-iodotolene from p-toluidine, NaBH4 reduction of vanillin, Preparation of umbelliferone by Pechhman reaction, Preparation of triphenyl imidazole, Microwave synthesis

Third

Research Methodology & Biostatistics

MRM 301T

4

M. Pharm (Pharmaceutical chemistry)

UNIT – III: Medical Research

Journal Club

MPH 302JC

2

M. Pharm (Pharmaceutical chemistry)

Research articles presentation

Discussion/Presentation

MPH303PP

4

M. Pharm (Pharmaceutical chemistry)

Assignment work

Research work

MPH304RW

14

M. Pharm (Pharmaceutical chemistry)

Research project

Fourth

Journal Club

MPH 401JC

2

M. Pharm (Pharmaceutical chemistry)

Research articles presentation

Research work

MPH402RW

18

M. Pharm (Pharmaceutical chemistry)

Research project

Discussion/Presentation

MPH403PP

4

M. Pharm (Pharmaceutical chemistry)

Assignment work

1. Synthesis of novel chemotypes

2. Synthetic method development: Transition metal catalyzed C-H activation, Pd-catalyzed azide-isocyanide cross coupling reactions, multicomponent reactions

3.  Computationl study for unfolding of RNA and Proteins

4. Synthesis of radionucelid ligands

S. No. Authors Title of Article Journal/Conference Details Journal/Conference Publication Year
1 1. Elagandhula Sathish, Arshad J Ansari, Gaurav Joshi, Akansha Pandit, Monika Shukla, Neha Kumari, Ashoke Sharon, Ved Prakash Verma, Devesh M Sawant. Pd-catalysed [3+ 2]-Cycloaddition towards the generation of bioactive bis-heterocycles/Identification of COX-2 inhibitors via in silico analysis Org. Biomol. Chem. 2022, 20, 4746-4752. Journal 2022

S.N.

 Year

Amount (Lakhs)

Status

Title of the Project

Sanction Number

Funding Agency

1

2018

60.89

Completed

Design, synthesis and characterization of multifunctional platform for targeted-tumor therapy (as PI)

EMR/2016/008016

SERB

2

2017

25.66

Completed

A divergent syntheses of benzothiazoles via direct C-H activation and their cytotoxic activity: A way to cancer research

EMR/2016/003969

SERB

3

2015

15.50

Completed

Design of FRET assay for quantitative and high-throughput screening of deubiquitinase inhibitors

02(0201)14/EMR-II

CSIR

4

2014

24

Completed

Design and Synthesis of Selective Irreversible Inhibitors of Trypanothione Reductase as Antileishmanial Agents

SB/FT/CS-012/2014

SERB

5

2014

6

Completed

Design, synthesis and screening of acridine-based trypanothione reductase Inhibitors as antileishmanial agents

F.30-18/2014/(BSR)

UGC

6

2012

6

Completed

Design and synthesis of new natural product-inspired chemotypes against P. falciparum

OC_RNIPER_00001

CSIR

Attended

Invited Lectures/Talk:

  1. Delivered Invited talk in Interactions 2020 on “Azide-Isocyanide Cross Coupling Reaction promoted by Pd-Catalysts: Applications in Medicinal Chemistry and Bioimaging” from February 6-7, 2020 at IISER, Bhopal on 7th February 2020.
  2. Delivered Invited talk in 26th Indian Society for Chemists and Biologists Conference on “Pd-Catalyzed Azide-Isocyanide Cross Coupling Reaction: Applications in Medicinal Chemistry and Bioimaging” from 22nd to 24th January 2020 at NIRMA University, Ahmedabad on 22nd January 2020.
  3. Deliver invited talk in “National Conference on, “Trends and Innovation in Chemistry” (NCTIC-19) on “Exploration of Pd-Catalyzed Azide-Isocyanide Cross Coupling Reaction” from 6th to 7th Deember 2019 at Ravindranath Tagore Group of Colleges, Kapasan on 7th December 2019.
  4. Deliver invited talk on “Mechanistic Investigation of Organic Reactions: Development of higher order multicomponent reactions and its applications” on  12th April, 2019 at Lovely Professional University, Phagwara, Punjab.
  5. Deliver invited talk in Recent Advances in Organic and Bioorganic Chemistry (RAOBC-2019) on “Bimetallic Relay Catalysis Driven by Nitrene-Transfer on Isocyanide: Promising Applications in Medicinal Chemistry and Bioimaging” from 22nd to 24th March, 2019 at IISER, Mohali on 24th March 2019.
  6. Deliver invited talk in International Conference on Functional Nanomaterials (ICFNM-2019) on “Transition-Metal Catalyzed Synthesis of Bioactive Heterocycles and Their Application in Nanomaterials” from 23nd to 25th February, 2019 at IIT, BHU on 24th February 2019.
  7. Deliver invited talk in Science Academies Refresher Course on “Upskilling Chemistry Teachers on latest Pedagogical tools for Impactful Teaching” from 27st November to 11th December 2018 at Vignan University, Guntur on 4th -5th December 2018.
  8. “A Short History of the Discovery and Development of Modern Pharmaceuticals” at ICMR sponsored national workshop on Biostatistics, Epidemiology and Research Methodology (BERM-2018) on 23rd February 2018 held at Vignan Pharmacy College, Guntur from 23rd and 24th February 2018.
  9. “Transition-metal catalyzed novel and sustainable strategies for the synthesis of bioactive heterocycles” at 24th International ISCB conference (ISCBC-2018) on 12th January 2018 held at Manipal University, Jaipur from 11th to 13th January 2018.
  10. “Ruthenium-catalyzed C-H Functionalization for the Construction of Bioactive Heterocycles” at Contemporary Facets in Organic Synthesis (CFOS-2017, national conference) on 23rd December 2017 held at Indian Institute of Technology, Roorkee             from 22nd to 24th December 2017.
  11. “Transition-metal catalyzed new strategies for the synthesis of nanomaterials” at Advances in Biological Systems and Materials Science in NanoWorld (ABSMSNW-2017, international conference) on 22nd February 2017 held at Indian Institute of Technology (BHU) Varanasi, UP, between 20-23 February 2017.
  12. “Understanding drug research and development” at DST INSPIRE Internship Science Camp on December 18, 2016 held at Central University of Rajasthan, Ajmer between 14-18 December 2016 (National).
  13. “Transition-metal catalyzed new strategies for the synthesis of bioactive heterocyles” at one-day National Symposium on Emerging Trends in Applied Chemical Sciences (ETACS-2016) on March 18, 2016 held at Central University of Rajasthan, Ajmer.
  14. “Development of highly sustainable approach towards synthesis of bioactive heterocycles” at National Conference “Green Chemistry and Sustainable Technologies for Society (NCGCSTS 2016)” on 11th January 2016 held at Government Women Engineering College, Ajmer during 11th  to 12th January 2016.
  15. “Application of new synthetic methodologies for generating bioactive heterocycles” at conference “Current Challenges in Drug Discovery Research (CCDDR 2015, International Conference)” on 24th November 2015 held at Malviya National Institute of Technology (MNIT), Jaipur during 23rd to 25th November 2015.
  16. “Exploring new pathways for the synthesis of bioactive heterocycles using Transition-Metal catalyst” at National Conference held at CDRI, Lucknow on “Trends in Synthesis of Bioactive Agents” held on July 30, 2015.
  17. “Exploration of biologically accessible chemical space using new synthetic methodologies” at National Conference on Frontiers at the Chemistry - Allied Sciences Interface (FCASI-2015) at Rajasthan University, Jaipur held on March 13-14, 2015. Website: http://fcasi2015.wix.com/fcasi2015.
  18. “Pictet-Spengler reaction: a new direction to century old reaction” presented at Junior National Organic Symposium Trust (J-NOST) at Jaipur (held between 11th to 14th Oct. 2006) on 12th Oct 2006.

Posters:

  1. Devesh Sawant. Development of new multicomponent reactions driven by azide-isocyanide denitrogenative coupling reactions. 23rd CRSI National Symposium in Chemistry organized by IISER, Bhopal held between 13th and 15th July 2018.
  2. Devesh Sawant. Transition metal-catalyzed C-H functionalization and multicomponent reactions for the construction of bioactive heterocycles. 22nd CRSI National Symposium in Chemistry organized by Pt. Ravishankar Shukla University, Raipur held between 2nd and 4th February 2018.
  3. Devesh Sawant. One pot methodology for the synthesis of pyrone via tandem transesterification and alkenylation of enynoates. International conference on frontier at the Chemistry-Allied Sciences Interface (FCASI-2017) at Rajasthan University, Jaipur held between 22-23 July 2017.
  4.           Devesh Sawant and Bijoy Kundu. Application of Modified Pictet-Spengler Reaction for the Synthesis of novel heteroaromatic Polycyclic Structures. Chemical Research Society of India  (CRSI) National Symposium in Chemistry at Indian Institute of Science (IISc), Bangalore (held between 1st to 3rd Feb 2008) on 2nd Feb, 2008 (Poster presenter).
  5.           Devesh Sawant, Srinivas Duggineni, Rishi Kumar, Prakas R. Maulik and Bijoy Kundu. Unprecedented SnCl2 mediated N-N bond formation leading to novel heterocyclic frameworks. International Conference on Organic Chemistry and Chemical Biology-2006, at National Chemical Laboratory (NCL), Pune (held between 6th to 9th Feb 2006) on 8th Feb, 2006 (Poster prosenter).
  6.           Devesh Sawant and Bijoy Kundu. A Modified Pictet-Spengler Reaction Leading to the Synthesis of Versatile Heterocycles. National Symposium on “Innovative Methods in Chemistry Education (IMCE-2005) held at Lucknow University on 22nd October 2005.
  7.           Devesh Sawant, Biswajit Saha and Bijoy Kundu. Polymer Supported Synthesis of Benzimidazoquinazoline. Chemistry Biology Interface: Synergistic New Frontiers-2004 at University of Delhi; 21st Nov, 2004 (International Conference).

Workshop/Training: 

  1. Attended Ten Days Workshop on Teaching-Learning & Evaluation for faculty members of HEIs at TLC Centre of Central University of Rajasthan, Ajmer from 4th -14th, November, 2019.
  2. Attended Ten Days Workshop on Teaching-Learning & Evaluation for faculty members of HEIs at TLC Centre of Central University of Rajasthan, Ajmer from 15th -24th, December, 2018.
  3. Attended Summer Program (equivalent to one refresher course) organized by UGC-Human Resource Development Centre, Guru Nanak Dev University, Amritsar from June 16, 2017 to July 06, 2017.

Organized

  1. Organized Three Days Training Workshop on “Effective Teaching/Learning Methods for Science Teachers of Schools” from 7th -9th February, 2019 at The Teaching Learning in Central University of Rajasthan.
  2. Co-coordinator First DST INSPIRE Science Camp at Central University of Rajasthan, 14-18th December 2016. An overwhelming response was received for the first camp, a total of 187 students and 20 escort teachers from 20 schools across Rajasthan participated in this camp. Very eminent scientists all over India have interacted with students for five days.
  3. Organized one-day outreach activity “Drug Awareness Camp” on 22nd September 2016 in Central University and nearby villages.
Title Attachment File Other Link
URL https://sites.google.com/site/sawantlabcuraj/group