Department of Biochemistry is at the heart of this University and provides a feather to the University by offering tremendous potential in basic as well as applied sciences. Department of Biochemistry, Central University of Rajasthan came into existence in July 2012 under the School of Life Sciences. The mandates of the department are to undertake post-graduate teaching, enable students to compete in national/international scholarship examinations e.g. CSIR & UGC NET-JRF, ICMR-JRF, GATE, abroad PhD entrance exam etc. The department also envisions extending in the field of biochemical broad areas which includes Biomolecular Structure and Dynamics, Cancer Biology, Host-pathogen interaction, Infectious Diseases, Glycobiology, Drug Discovery, Vaccine design, Nanomedicine and Molecular Medicine. The department is boosted by highly qualified young talented faculties with PhD training from prestigious Institutions/Universities like All India Institute of Medical Sciences, New Delhi; Indian Institute of Technology, Kharagpur; University of Hyderabad; Banaras Hindu University; Indian Institute of Technology, Kanpur, and Jawaharlal Nehru University. The research activity of the department has been supported by various funding agency, DST-RFBR, SERB, DBT, UGC etc. Research output of the department has been recognised by various national academy like Indian National Science Academy (INSA-Young Scientist Award), Indian Council of Medical Research (ICMR-Award), National Academy Agricultural Science (NAAS-Young Scientist Award), and Indian Science Congress etc. The master students of the department have been qualified various national level examinations like CSIR-JRF, UGC-JRF, GATE etc and pursuing higher studies in various national (IGIB, AIIMS, CCMB, IMTech etc) and international institutes (South Korea, Taiwan etc). Department offers Int. M.Sc., M.Sc. and Ph.D. and student get admitted through all India basis CUCET examinations. Our classrooms are well equipped with modern facilities for teaching which includes LED projector, white board, regular board and digital board. Our laboratory is equipped with instruments needed for the basic research which includes Centrifuge, incubator, electrophoresis unit, deep fridge, animal cell culture, bacterial cell culture, bioinformatics computers, hoods, pH meter etc. The objectives of the department are-

  • To ignite young minds, from different backgrounds, to understand the world of biochemical reactions through application based learning. This learning would develop their reasoning power and train them for career in research as well as to qualify various national and international level examinations.
  • To provide high quality teaching to the students through traditional classroom teaching and modern audio-visual aids and hands on training on various aspects of biochemistry and allied biological subjects. 
  • To develop scientific skills and personality development of students by various departmental and university level activities. 
  • To motivate students for high quality research and innovation at PG and Ph.D. level for social welfare and sustainable health.
  • To encourage interdisciplinary learning by giving option to students for audit courses offered by other departments.

M. Sc. Biochemistry

Objectives of the program:

The Students of M.Sc. Biochemistry programme will learn experimentally and theoretically about the chemistry of biological phenomenon of living organisms. The course aims to provide the skills of identifying scientific issues, developing hypothesis based on literature, designing experiments and displaying results for betterment of mankind.

To provide high quality research oriented teaching that trained them to qualify various national and international competitive examinations like CSIR, & UGC NET-JRF, ICMR-JRF, GATE, abroad PhD entrance exam and industries.

Intake and eligibility:

23 students with Bachelor’s degree with Biochemistry/ Zoology/ Botany/ Life Sciences/ Microbiology/ Genetics/ Biotechnology/Medicine/Pharmacy/any other discipline of Biological sciences as one of the main subjects and Chemistry as one of the optional subjects at least for One year or Two semesters with minimum 50% of marks or equivalent grade in aggregate for general category and 45% or equivalent grade for SC/ST/OBC/PWD candidates.

Integrated M. Sc. Biochemistry

Objectives of the program:

The students of integrated M.Sc. Biochemistry programme will acquire fundamental knowledge in the diverse biological subjects along with gaining of basic concept in various relevant interdisciplinary subjects including chemistry, mathematics and physics. In addition, the Students will learn experimentally and theoretically about the chemistry of biological phenomenon of living organisms.  The course aims to provide the skills of identifying scientific issues, developing hypothesis based on literature, designing experiments and displaying results for betterment of mankind.

To encourage interdisciplinary learning of students and promoted them to be a future leader in biological science.   

Intake and eligibility: 30 students with 10+2 in Science stream or equivalent of any recognized board in India with Biology as one of the optional subjects having 50% marks or equivalent grade in aggregate  for general category and 45% or equivalent grade for SC/ST/OBC/PWD candidates.

Doctor of Philosophy

Objectives of the program:

The research scholars of Ph.D. Biochemistry programme will acquire fundamental and molecular insights in the recent advancement of biological chemistry along with various thrust research areas with simultaneous enhancement of knowledge in framing new research proposal and scientific writing. During this training period, students will get a strong exposer to learn various basic and modern research techniques along with gaining a self-confidence to be an independent researcher and critical thinker.    

To motivate students for high quality research for sustainable health and social welfare.

Intake and eligibility:

5-10 students and eligibility  Master degree with Biochemistry/Microbiology/ Biotechnology/Zoology/Botany/relevant discipline)

Regular

Dr. Bhawana Bissa

Assistant Professor

M.Sc. (Biochemistry), Ph.D. (Biochemistry; AIIMS, New Delhi), Postdoctoral Training: Ohio State University, Columbus, USA; University of New Mexico, Albuquerque, USA

bhawana.bissa@curaj.ac.in

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Prof. Chandi C. Mandal

Professor

M.Sc. (Biochemistry; Calcutta University), Ph.D. (Biotechnology; IIT-Kharagpur), Postdoctoral Training (University of Texas Health Science Center at San Antonio, Texas, USA), CPRIT Fellowship (USA-Govt.); ASBMR Young Investigator Award

ccmandal@curaj.ac.in

91

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Dr. Dipak Gayen

Assistant Professor

M.Sc. (Biochemistry; Calcutta University), Ph.D. (Biochemistry; Calcutta University), Postdoctoral Training (NIPGR, New Delhi; Cornell University, Ithaca, USA), INSA-Young Scientist, NASI-Young Scientist, Fulbright Fellow.

dipak.gayen@curaj.ac.in

9836079405

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Dr. Kiran Kumar Tejavath

Assistant Professor

M.Sc. (Biochemistry), Ph.D. (Biochemistry; UoH), CSIR/UGC NET JRF JRF

kirankumar@curaj.ac.in

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Prof. Sanjib Kumar Panda

Professor and Head

M.Sc. (Gold Medalist), M.Phil., Ph.D., D.Sc. (Utkal University), JSPS Fellowships (JAPAN), BOYSCAST Fellow at University of California, Riverside, JSPS-BRIDGE Fellow, IUSSTF Fellow at UNC, Chapel Hill & OSU,USA, INSA visiting Scientist, GERMANY

sanjib.panda@curaj.ac.in

9435370608

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Dr. Shiv Swaroop

Assistant Professor

M.Sc. (Biochemistry), Ph.D. (Biological Sciences and Bioengineering; Indian Institute of Technology, Kanpur), Postdoctoral Training: Molecular Biophysics Unit, Indian Institute of Science. CSIR-UGC NET- JRF; GATE, DBT Research Associate Fellowship

shivswaroop@curaj.ac.in

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Dr. Vijay Kumar Prajapati

Assistant Professor

M.Sc. (Biochemistry), Ph.D. (Biochemistry, Department of Medicine, IMS-BHU), Postdoctoral Training- University of South Alabama, Alabama, USA.

vkprajapati@curaj.ac.in

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Dr. Vishvanath Tiwari

Assistant Professor

M.Sc. (Biochemistry), Ph.D. (Biochemistry; AIIMS, New Delhi), CSIR-NET-JRF; ICMR-JRF; GATE; Young Scientist Medal-Indian National Science Academy; Associate-Indian Academy of Sciences; Member-National Academy of Sciences

vishvanath@curaj.ac.in

8503002573

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Other

Dr. Dhaneswar Prusty

Assistant Professor (UGC)

M.Sc. (Tezpur University, Assam); CSIR NET- JRF; DBT- JRF; GATE; PhD (Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi); Post-doctoral Research (Department of Pathology and Molecular Medicine, McMaster University, Hamilton

dhaneswarprusty@curaj.ac.in

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Department have different instruments like spectrophotometer (UV-Vis), electrophoresis units (agarose, PAGE & 2D), deep freezer (-80°C,-150°C), incubator (CO2, BOD), gradient PCR, compound microscope, inverted microscope, blot scanner, nano spectrophotometer, gel-doc, ice flaker, culture hoods (BSL-2), incubator shaker and centrifuges. Department has also an extensive access for the most sophisticated instruments such as FPLC, Ultra centrifuge, Real time PCR, Fluorescence microscope of  the School of Life Sciences. Provision of health and safety measures for the laboratory students and researchers has also been made.  The students are getting hands on training in the basic areas like Biochemical techniques including estimation of biochemical compounds, isolation and identification of microorganism in different environmental samples, protein and DNA-gel electrophoresis, Chromatography techniques, Immunological methods, Genomic and Plasmid DNA isolation, Plasmid DNA transformation, Polymerase Chain Reaction, Cloning, Enzyme Kinetics, Clinical Biochemistry and Plant Biochemistry.

 

1. Laboratory of Prof. Sanjib K Panda

Prof. Sanjib K. Panda’s lab works in the area  of Plant Molecular Biology  & Plant Functional Genomics to understand the mechanisms of abiotic stress signal transduction and to develop stress tolerant crop plants. Various  functional genomics platforms are used to dig high-throughput transcriptome and  miRNome data deciphering the gene expression and transcriptional gene regulation. With transgenic and genome editing technology unique critical gene/Tfs/miRNA is functionally validated to understand  stress tolerance in model plant and crop systems.

2. Laboratory of Dr. Chandi C Mandal

Dr. Mandal’s research interest is aimed at understanding the cellular signal transduction mechanisms involved in breast cancer, bone metastasis and calcification using molecular and cellular biology techniques and clinical sample analysis. Dr. Mandal presently focuses his research area on  i) finding the molecular mechanism involved in  cancer-associated bone metastasis ii) prevention of microcalcification in breast cancer, iii) finding the molecular pathways involved in stress induced epigenetic changes in  tumorigenesis. Dr. Mandal’s newly developed interests on bone metastasis of breast cancer and signalling crosstalk of osteoblast and osteoclast cells have been very significant insight into molecular mechanism of these diseases.

3. Laboratory of Dr. Vishvanath Tiwari

Dr. Vishvanath Tiwari’s lab mainly focuses on pathogenesis, drug resistance, therapeutics development for ESKAPE pathogens (Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae) causes hospital-acquired infections. His current research interest includes i) Antimicrobial and Antibiotic Resistance (Mechanism; Therapeutics), ii) Host-pathogen interaction (Mechanism; Signaling; Autophagy; Immunomodulation), iii) Bacterial Pathogenesis (Biofilm; Persistence; Quorum Sensing)iv) Vaccine Design and Drug Discovery (Chimeric design molecule), v) Nanomedicine and herbal medicine vi) Antimicrobial peptides (AMP) and Antibiotic induced Allergy, vii) Role of unusual DNA, and RNA in bacterial pathogenesis, viii) Protein Engineering and Structural biology (Molecular evolution; Protein folding) 

4. Laboratory of Dr. Kiran Kumar Tejavath

Dr. Kiran Kumar Tejavath Lab is mainly focusing on the herbonanoceuticals, a nanotechnological approach to herbal drugs used in the anticancer research. Synerigetic effect of the herbal and pharma drugs in treatment of various diseases like cancer, diabetes, hypertension, infectious diseases etc. These nanoparticles are prepared using the biocompatible nano polymers which find potential application as an effective, safe and economic nanoformulations for the treatment of above said diseases. Main focus is given to the translational clinical research, bioavailability, effect on target site, slow release at the target site using different nano drug delivery systems which include bio compatible nanopolymers.

5. Laboratory of Dr. Vijay Kumar Prajapati

Dr. Prajapati’s research interest is aimed to investigate new active biomolecules against different kind of infectious diseases such as Visceral leishmaniasis. Dr. Prajapati presently focuses his research area on  i) finding the molecular mechanism involved in  killing of Leishmania donovani by antileishmanial drugs ii) Investigating bioactive molecules against infectious diseases, iii) Development of vaccine against infectious diseases. His lab is working on the vaccinology to develop potent vaccine molecules by using system vaccinology.

6. Laboratory of Dr. Shiv Swaroop

Dr. Shiv Swaroop’s lab is mainly focusing on developing the protein based vaccines and antiviral drugs against some common viruses. Vaccine design work requires extensive protein engineering work that needs thorough understanding of protein structure and stability concepts. Engineered proteins need lot of optimization for their expression in soluble native like structure. Thus, engineered proteins are also stabilized by rational mutagenesis which is important from both the structural and functional point of view. For drug discovery, various computational methods to study protein-protein and protein-drug interactions are utilized. In silico studies will be supplemented with in vitro studies to check the interaction of potential drugs with expressed proteins. Another area of interest of this lab is to isolate industrially and pharmaceutically important enzymes from the hypersaline extremophiles by using recombinant DNA and protein purification techniques.

7. Laboratory of Dr. Dhaneswar prusty

The effort towards malaria eradication is going to be seriously hampered due to increasing resistance in malaria parasites against all existing drugs and lack of an effective vaccine. Thus our lab is focused on two different areas of malaria biology. The first focus is on the bioinformatics and biochemical analysis of different putative drug targets of the housekeeping functions of apicoplast; a non-photosynthetic plastid like organelle has been proved to be essential for parasite survival. The second research focus is on the exploration of exclusive metabolic pathways of malaria parasite.

8. Laboratory of Dr. Dipak Gayen

Dr. Dipak Gayen’s lab is focused on the elucidation of organelle proteomics study in response to several environmental stress, which is used extensively for better understanding at the cellular level. Dr. Gayen is currently focussing on (i) protein homeostasis of chloroplast and mitochondria through protease system (ii) chloroplast plastoglobules (PG) (iii) Unfolded Protein Response (UPR) of mitochondria (iv) functional characterization novel candidate genes of chloroplast and mitochondria and (v) phosphoproteomics study. The major target is to identify the regulatory pathways which would provide direction for designing improved crops for sustainable agriculture.

9. Laboratory of Dr. Bhawana Bissa

Dr. Bhawana Bissa’s lab is focused to understand the role of autophagy in cancer metabolic reprogramming and cellular senescence. The metabolic stress in advanced tumors as well therapy-induced stress can stimulate dependence on autophagy. While there has been lot of studies on cell autonomous functions of autophagy, the non-cell autonomous functions affecting the tumor microenvironment are poorly studied. Dr. Bhawana is primarily focused to understand (i) Role of autophagy in tumor metabolic reprogramming (ii) Non-cell autonomous functions of autophagy (iii) Autophagy and cellular senescence (iv) Lysosomal function in autophagy pathway (v) Apoptosis and Autophagy crosstalk in cancer chemoresisitance

Name of the Investigator

Title of the project

Amount sanctioned (in Lakhs)

Funding Agency

Status

Duration

Prof. Sanjib K. Panda Whitefly (Bemisia tabaci) in North Eastern India. Diversity, factors of virus transmission and natural inhibitor

 PI (30.29) Total110

DBT-Twinning On-going 2018-2021
Prof. Sanjib K. Panda Genome and transcriptome sequencing of aromatic rices from Northeasthern regions 46.63 DBT Completed 2016-2019
Prof. Sanjib K. Panda Functional Genomics for Drought Tolerance in Assam Rice 37.05 DBT On-going 2016-2020

Chandi C Mandal

Cholesterol-lowering Drug Targets Osteoclastogenic Factors to Prevent Osteolytic Bone Metastasis of Breast Cancer

25.0

DBT

On-going

2015-2019

Chandi C Mandal

Influence of Diabetes on Bone Metastasis of Breast Cancers

6.0

UGC

Completed

2014-2017

Vishvanath Tiwari

Interaction studies of the Acinetobacter baumannii with the human cell model

24.2

SERB- DST

Completed

2014-2018

Vishvanath Tiwari

Differential expression of the IROMPs in sensitive and resistant strain of Acinetobacter baumannii

6.0

UGC

Completed

2014-2017

Vishvanath Tiwari

Designing and experimental validation of Inhibitor for RecA protein of Acinetobacter baumannii: an addition to the current antibiotics and disinfectants

28.2

SERB- DST

On-going

2018-2021

Kiran Kumar Tejavath

Heavy metal removal and conformational stability of the Moringa oleifera coagulant protein (MOCP) a homodimeric protein from Moringa oleifera

6.0

UGC

Completed

2014-2017

Kiran Kumar Tejavath

Investigating Anticancer Potential of Biosynthesized Silver Nanoparticles and Polymeric Nanoparticles Using Medicinal Plants of Rajasthan, INDIA

45.71

SERB-DST

On-going

2017-2020

Vijay Kumar Prajapati

Antileishmanial activity of silver nanoparticles attached to amphotericin B

6.0

UGC

Completed

2014-2017

Vijay Kumar Prajapati

Development of natural product derived febrifugineananlogues as a novel therapeutics against visceral leishmaniasis

29.76

SERB-DST

On-going

2016-2018

Chandi C Mandal (Co-PI)

Rationally designed Indolizine derivative(s) as multitarget anticancer agent for inhibition
of cancer cell growth and metastasis

14.0

SERB-DST

 Completed 

2015-2017

Vijay Kumar Prajapati (Co-PI)

Molecular and Structural Characterization of Mitochondrial DNA Primase in Leishmania donovani

119.51

 

DBT

DBT-Twin North-east)

2016-2019

Dr. Chandi C Mandal

Interplay of metabolic and signal pathways of N-acyl dopamines and cholesterol in cancer cells

16.45

DST-RFBR

(Indo-Russia)

On going

2017-2019

Dipak Gayen

Identification and functional characterization of chloroplast Clp protease from chickpea (Cicer arietinum L.) in response to heat stress.

10.0 UGC  Sanctioned 2019-2021
Bhawana Bissa Understanding the molecular regulation of autophagy during breast cancer metastasis 10.0 UGC Sanctioned 2019-2021
Bhawana Bissa Exploring the role of 'Secretary Arm of Autophagy' in Glioblastoma therapy resistance: an in vitro and patient data based study 37.84 ICMR-EMR Sanctioned 2020-2023
Achievement Title Attached File

Prof. Sanjib K Panda-

  • Extraordinary Professor, Stellenbosch University, South Africa, 2019-2022
  • Visiting Professor, Universitas Sebalas Maret (UNS), Indonesia, 2019
  • UNESCO-TWAS ASSOCIATESHIP, 2018, National Centre for Genetic Engineering & Biotechnology (BIOTECH) Thailand
  • Visiting  Professor, Shizuoka  University, JAPAN,2018, 2019
  • Fellow  ,ROYAL SOCIETY OF BIOLOGISTS, London, UK, 2017
  • Asian Visiting Professor , Chubu Foundation, Shizuoka University, Japan, 2016
  • Adjunct Professor, Gifu University, JAPAN
  • Visiting  Professor, Gifu University, JAPAN, 2015-2016,2016-2017,2017-18,2018-2019
  • Visiting Professor , Irkutsk National Research Technical University, RUSSIA
  • CEPLAS Guest Visiting Professor, Institute Botanik, University of Dusseldorf, GERMANY, 2015
  • Indo-US Science & Technology Forum Fellowship (IUSSTF) , University of North Carolina, Chapel Hill, USA, & Oklahoma State University, Stillwater, USA, 2013-2014.
  • INSA-DFG Visiting Scientist, IZMB, University of Bonn, GERMANY, 2013.
  • JSPS-BRIDGE Fellowship, Faculty of Applied Biological Sciences, Gifu University, JAPAN, 2011.
  • BOYSCAST Fellowship, University of California, Riverside, USA, 2009-2010.
  • French Govt. Scholarship, BPMP, Montpollier, FRANCE,2009 (Not availed)
  • UGC Visiting Professor, ARI, Hungarian Academy of Sciences, Martovasor, HUNGARY, 2009 (not availed)
  • JSPS-Post Doctoral Fellowship, Institute of Plant Science & Resources, Okayama University, JAPAN, 2003-2005.
  • Young Scientist Award, Orissa Botanical Society, INDIA, 1996.

Dr. Vishvanath Tiwari-

  • Dr. Vishvanath Tiwari, has received “INSA-Young Scientist Award-2018” by Indian National Science Academy (INSA), New Delhi
  • Dr. Vishvanath Tiwari, has recognized as "Associate-2019" by Indian Academy of Sciences (IASc). Bengaluru.
  • Dr. Vishvanath Tiwari, has recognized for "Membership-2020" by the National Academy of Sciences, India (NASI).
  • Dr. Vishvanath Tiwari, has received “Chancellor's Award for Best Faculty-2019" by Central University of Rajasthan, Ajmer
  • Dr. Vishvanath Tiwari, has received “Dr. G.G. Memorial Award for Young Scientist in Animal Science-2018” by Indian Science Congress Association, Govt. of India
  • Dr. Vishvanath Tiwari, has received “Venus International Faculty Awards for Young Faculty in Science-2017”
  • Dr. Vishvanath Tiwari, has received “ICMR Award (Shakuntala Amir Chand Prize)-2016” by Indian Council of Medical Research (ICMR), New Delhi.

Dr. Vijay Kumar Prajapati-

  • Dr. Vijay Kumar Prajapati, has received “Prof. Umakant Sinha Memorial Award-2018-19” by Indian Science Congress Association (ISCA), Govt of India
  • Dr. Vijay Kumar Prajapati, has received “Young Scientist Award-2018” by Associations of Microbiology of India (AMI).
  • Dr. Vijay Kumar Prajapati, has received “Young Scientist Award-2018” by Indian Society of Chemists and Biologist (ISCB).
  • Dr. Vijay Kumar Prajapati, has received Chancellor's Award for Best Faculty-2018 by Central University of Rajasthan, Ajmer
  • Dr. Vijay Kumar Prajapati, has received “Young Scientist Award-2017” by  National Academy of Agricultural Sciences (NAAS), New Delhi
  • Dr. Vijay Kumar Prajapati has been recognized as Associate-2017 by National Academy of Agricultural Sciences (NAAS).
  • Dr. Vijay Kumar Prajapati, has received “Young Scientist Award-2016” by Biotechnology Research Society, India (BRSI).
  • Dr. Vijay Kumar Prajapati has been recognized as Associate-2016 by Indian Academy of Sciences (IASc). Bengaluru.
  • Dr. Vijay Kumar Prajapati recognized as ASM-IUSSTF Indo-US Research Professorship-2016 from American Society for Microbiology (ASM) and Indo-US Science and Technology Forum (IUSSTF).
  • Dr. Vijay Kumar Prajapati, has received “INSA-Young Scientist Award-2015” by Indian National Science Academy (INSA), New Delhi
  • Dr. Vijay Kumar Prajapati, has received “ICMR Award (Shakuntala Amir Chand Prize)-2014” by Indian Council of Medical Research, New Delhi.

Dr. Dipak Gayen-

  • Dr. Dipak Gayen has received “INSA- Medal for Young Scientist Award -2017” by Indian National Science Academy, New Delhi.
  • Dr. Dipak Gayen, has received “NASI-Young Scientist Platinum Jubilee Award -2018” by National Academy of Science India, Allahabad
  • Dr. Dipak Gayen has received “Fulbright Fellow-2018” (Cornell University, USA) by United States-India Educational Foundation (USIEF)

Dr. Bhawana Bissa-

  • Best Poster Award at YIM-IIT Jodhpur, Nov 2019
  • US Patent: FAT1 gene in cancer and Inflammation. US 9556437 B2 Inventors: Kunzang Chosdol, Bhawana Dikshit, Subrata Sinha. 2017
  • Awarded CSIR Nehru Post Doctoral Fellowship, 2013
  • International Travel Award from Council for Scientific and Industrial Research (CSIR), 2013
  • Awarded AIIMSONIAN Dr. Arun Fotedar Memorial Award, 2012
  • International Travel Award from Department of Science and Technology (DST), 2011

 

Department of Biochemistry

CENTRAL UNIVERSITY OF RAJASTHAN
NH-8, Bandar Sindri,
Dist-Ajmer-305817, Rajasthan [INDIA]

: hod.biochem@curaj.ac.in