Personal Information
Dr. Bhawana Bissa
Assistant Professor
M.Sc. (Biochemistry), Ph.D. (Biochemistry; AIIMS, New Delhi), Postdoctoral Training: Ohio State University, Columbus, USA; University of New Mexico, Albuquerque, USA
9352061667
- Functional Genomic analysis of autophagy process in tumorigenesis.
- Delineating the crosstalk between autophagy and exosome pathways
- Unraveling Metabolic heterogeneity in tumors by dissecting role of autophagy in cancer metabolism
https://scholar.google.co.in/citations?hl=en&user=FJZVOnAAAAAJ&view_op=list_works&sortby=pubdate
Educational Qualifications
07/2007-04/2013 PhD thesis “Characterization of FAT1 pathway in human glial tumorigenesis”, Dept. of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
07/2003-03/2007 M.Sc (Med.) Biochemistry thesis “Analysis of serum iron and ceruloplasmin levels in adolescent girls”, Dept. of Biochemistry, Dr. S.N. Medical College, Jodhpur, Rajasthan, India
07/2000-03/2003 Bachelor of Science in “Chemistry, Botany, Zoology”, Lachoo Memorial College, Jodhpur, JNV University, Rajasthan, India with overall “80.5%” marks
07/1998-03/1999 Senior Secondary exam in “Biology, Physics, Chemistry” from St. Patricks school, Jodhpur, Rajasthan Board with overall “80.3%” marks
07/1996-03/1997 Secondary school exam from St. Patricks school, Jodhpur, Rajasthan Board with overall “79.8%” marks
Stipends, Awards and Memberships:
03/2007 Junior Research Fellowship (2007-2009) and Senior Research Fellowship (2009-2012) by Council of Scientific and Industrial Research (CSIR), India
| 03/2011 | Associate member of American Association of Cancer Research (AACR) |
| since March 2011 | |
|
09/2011 |
Travel grant from Dept. of Science and Technology (DST), Govt. of India to |
| present poster in AACR Int. Conference ‘Frontiers in Basic Cancer Research’ | |
| held in San Francisco, CA, USA from 14-09-2011 to 18-09-2011 | |
|
09/2012 |
Awarded AIIMSONIAN Dr. Arun Fotedar Memorial Award for Best PhD |
| Research Paper, 2012 | |
|
05/2013 |
Travel Grant from Council for Scientific and Industrial Research (CSIR), |
| Govt. of India to present poster in Keystone symposia ‘The Hippo Tumor | |
| Suppressor Network’ held in Monterey, CA, USA from 19-05-2013 to 23-05-2013 | |
|
07/2013 |
Selected for prestigious CSIR Nehru Post Doctoral Fellowship |
| 11/2019 | Best Poster award at 'Young investigator's Meeting', IIT Jodhpur |
US Patent:
Title: FAT1 gene in cancer and Inflammation. US 9556437 B2 Inventors: Kunzang Chosdol, Bhawana Dikshit, Subrata Sinha. https://patents.google.com/patent/US9556437
Book Chapter:
Nuclear Factors Linking Cancer and Inflammation. Chosdol K, Bhagat M, Dikshit B, Madan E, Chattopadhyay P, Sinha S. Nuclear Signaling Pathways and Targeting Transcription in Cancer; Cancer Drug Discovery and Development, Springer 2014, pp 121-154
Poster presentations at Conferences:
- Best Poster Award at Regional -YIM 'Young Investigator's Meeting' 2019 held at Indian Institute of Technology-Jodhpur. Oct 31-Nov 1 2019.
- Poster presentation at the Keystone Conference on ‘Autophagy: From Model Systems to Therapeutic Opportunities’, Santa Fe, New Mexico, USA, 17-21 Feburary 2019
- Poster presentation at the AACR Annual Conference 2015, Philadelphia, PA, USA, 18-22 April 2015
- Poster presentation at the keystone symposia ‘The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer’ Monterey, CA, USA, 19-23 May 2013
- Poster Presentation in AACR 2nd Int. Conference on ‘Frontiers in Basic Cancer Research’, San Francisco, CA, USA, Sept. 2011
- Paper Presentation in 2nd International Conference on Stem Cells and Cancer (ICSCC- 2011), Pune, India, Oct. 2011
- Poster Presentation in AACR Int. Conference on ‘New Horizons in Cancer Research: Biology to Prevention to Therapy’, New Delhi, India, Dec. 2011
- Poster Presentation in 31st Annual Convention of Indian Association for Cancer Research & International Symposium on ‘Cancer Genomics and its Impact in the Clinics’, Mumbai, India, Jan. 2012
- Poster presentation in ‘The HIPPO Tumor Suppressor Pathway: A Brainstorming Workshop’ Villa Betania, Rome 22-23 April 2009
| S. No. | Authors | Title of Article | Journal/Conference Details | Journal/Conference | Publication Year |
|---|---|---|---|---|---|
| 1 | Jingyue Jia*, Bhawana Bissa*, Lukas Brecht*, Lee Allers Seong Won Choi Yuexi Gu Mark Zbinden Mark R. Burge Graham Timmins Kenneth Hallows Christian Behrends Vojo Deretic *equal contribution | AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System | Molecular Cell DOI:https://doi.org/10.1016/j.molcel.2019.12.028 | Journal | 2020 |
| 2 | Jingyue Jia, Aurore Claude-Taupin, Yuexi Gu, Seong Won Choi, Ryan Peters, Bhawana Bissa, Michal H. Mudd, Lee Allers, Sandeep Pallikkuth, Keith A. Lidke, Michelle Salemi, Brett Phinney, Muriel Mari, Fulvio Reggiori, Vojo Deretic | Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal | Developmental Cell December 05, 2019 DOI:https://doi.org/10.1016/j.devcel.2019.10.025 | Journal | 2019 |
| 3 | Gu Y, Princely Abudu Y, Kumar S, Bissa B, Choi SW, Jia J, Lazarou M, Eskelinen EL, Johansen T, Deretic V. | Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs | EMBO J. 2019 Oct 18:e101994. doi: 10.15252/embj.2019101994. | Journal | 2019 |
| 4 | Nair S, Strohecker AM, Persaud AK, Bissa B, Muruganandan S, McElroy Craig, Pathak R, Williams M, Raj R, Kaddoumi A, Sparreboom A, Beedle AM, Govindarajan R | Adult stem cell deficits drive Slc29a3 disorders in mice | Nat Commun 2019 Jul 3; 10(1):2943. doi: 10.1038/s41467-019-10925-3. 3. | Journal | 2019 |
| 5 | Bissa B, Deretic V. | Autophagosome Formation: Cutting the Gordian Knot at the ER. | Curr Biol. 2018 Apr 23;28(8):R347-R349. doi: 10.1016/j.cub.2018.03.015. | Journal | 2019 |
| 6 | Claude-Taupin A, Bissa B, Jia J, Gu Y, Deretic V. | Role of autophagy in IL-1β export and release from cells. | Semin Cell Dev Biol. 2018 Apr 5. pii: S1084-9521(18)30017-X. doi: 10.1016/j.semcdb.2018.03.012. | Journal | 2018 |
| 7 | Srivastava C, Irshad K, Dikshit B, Chattopadhyay P, Sarkar C, Gupta D, Sinha S, Chosdol K. | FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma. Int J Cancer. | 2018 Feb 15;142(4):805-812 doi: 10.1002/ijc.31092. Epub 2017 Oct 17. | Journal | 2018 |
| 8 | Bissa B, Beedle AM, Govindarajan R. | Lysosomal solute carrier transporters gain momentum in research. Clin Pharmacol Ther. | 2016 Nov;100(5):431-436. doi: 10.1002/cpt.450. Epub 2016 Sep 15. | Journal | 2016 |
| 9 | Madan E, Dikshit B, Gowda SH, Srivastava C, Sarkar C, Chattopadhyay P, Sinha S, Chosdol K. | FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma. | Int J Cancer. 2016 Dec 1;139(11):2570-82. doi: 10.1002/ijc.30386. Epub 2016 Aug 29. | Journal | 2016 |
| 10 | Irshad K, Mohapatra SK, Srivastava C, Garg H, Mishra S, Dikshit B, Sarkar C, Gupta D, Chandra PS, Chattopadhyay P, Sinha S, Chosdol K. | A combined gene signature of hypoxia and notch pathway in human glioblastoma and its prognostic relevance. | PLoS One. 2015 Mar 3;10(3):e0118201. doi: 10.1371/journal.pone.0118201. eCollection 2015. | Journal | 2016 |
| 11 | Dikshit B., Irshad K., Madan E., Aggarwal N., Sarkar C., Gupta D., Chandra P.S., Chattopadhyay P., Sinha S., Chosdol K. | FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells. | Oncogene, 2013 Aug 15;32(33):3798-808. | Journal | 2013 |
| 12 | Chosdol K, Dikshit B, Sinha S. | FAT1 (FAT tumor suppressor homolog 1 (Drosophila)) (Invited Atlas Contribution) | Atlas Genet Cytogenet Oncol Haematol. 2011; 15(9):717-720. | Journal | 2011 |
| 13 | Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V | AMPK Is Activated During Lysosomal Damage via a Galectin-Ubiquitin Signal Transduction System. | Autophagy | Journal | 2020 |
| 14 | Jia J, Claude-Taupin A, Gu Y, Choi SW, Peters R, Bissa B, Mudd MH, Allers L, Pallikkuth S, Lidke KA, Salemi M, Phinney B, Mari M, Reggiori F, Deretic V | MERIT, a Cellular System Coordinating Lysosomal Repair, Removal and Replacement. | Autophagy | Journal | 2020 |
| 15 | VA Subramanian, Ravindra Bairwa, Pradeep Sharma, Bhawana Bissa | Cancer cell's internal and external warriors: Autophagosomes and exosomes | Life Sciences, 2022 Jul 1;300:120552. doi: 10.1016/j.lfs.2022.120552 | Journal | 2022 |
As PI
1. UGC Start up- 10.0 Lacs "Understanding the molecular regulation of autophagy during breast cancer metastasis" 2020-2022
2. SERB Start up Research Grant 30 Lacs "Exploring non-cell autonomous functions of autophagy during metabolic reprogramming of tumor microenvironment" 2020-2022
3. ICMR Grant 37 lacs "Exploring the role of 'Secretary Arm of Autophagy' in Glioblastoma therapy resistance: an in vitro and patient data based study" 2021-2024
4. SERB-POWER Grant 39.58 lacs "Understanding transcriptional and epigenetic modulation of AMPK subunit expression during acquisition of cancer chemo- resistance" 2022-2025
Attended
Conferences:
- Best Poster award at Regional ‘Young Investigator meeting’ YIM held at IIT-Jodhpur, Rajasthan, 31 Oct to 02 Nov 2019
- Poster presentation at the Keystone Conference on ‘Autophagy: From Model Systems to Therapeutic Opportunities’, Santa Fe, New Mexico, USA, 17-21 Feburary 2019
- Poster presentation at the AACR Annual Conference 2015, Philadelphia, PA, USA, 18-22 April 2015
- Poster presentation at the keystone symposia ‘The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer’ Monterey, CA, USA, 19-23 May 2013
- Poster Presentation in AACR 2nd Int. Conference on ‘Frontiers in Basic Cancer Research’, San Francisco, CA, USA, Sept. 2011
- Paper Presentation in 2nd International Conference on Stem Cells and Cancer (ICSCC- 2011), Pune, India, Oct. 2011
- Poster Presentation in AACR Int. Conference on ‘New Horizons in Cancer Research: Biology to Prevention to Therapy’, New Delhi, India, Dec. 2011
- Poster Presentation in 31st Annual Convention of Indian Association for Cancer Research & International Symposium on ‘Cancer Genomics and its Impact in the Clinics’, Mumbai, India, Jan. 2012
- Poster presentation in ‘The HIPPO Tumor Suppressor Pathway: A Brainstorming Workshop’ Villa Betania, Rome 22-23 April 2009
Published Abstracts:
Triple negative breast cancer cells have higher dependence on mitophagy for their survival as compared to hormone positive breast cancer cells. (Published Abstract). Dikshit B, Rai A, Roy SS. Cancer Res 2015; 75(15 Suppl): Abstract nr 988. doi:10.1158/1538-7445.AM2015-988
FAT1: A novel regulator of cancer and inflammation. (Published Abstract) Dikshit B, Chattopadhyay P, Sinha S and Chosdol K. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1 doi: 10.1158/1538-7445.AM2013-4102
Overexpression of FAT1 in human GBM (glioblastoma multiforme) and high-grade glioma cell lines. (Published Abstract) Dikshit B, Chosdol K, and Sinha S. Cancer Research: September 15, 2011; Volume 71, Issue 18, Supplement 2 doi: 10.1158/1538-7445.FBCR11-A38
US Patent:
Title: FAT1 gene in cancer and Inflammation. US 9556437 B2 Inventors: Kunzang Chosdol, Bhawana Dikshit, Subrata Sinha. https://www.google.com/patents/US9556437
Book Chapter:
Nuclear Factors Linking Cancer and Inflammation. Chosdol K, Bhagat M, Dikshit B, Madan E, Chattopadhyay P, Sinha S. Nuclear Signaling Pathways and Targeting Transcription in Cancer; Cancer Drug Discovery and Development, Springer 2014, pp 121-154
| Title | Attachment File | Other Link |
|---|---|---|
| Autophagy Inducing Mechanisms and Processes in Response to Lysosomal Damage | https://www.flintbox.com/public/project/55681/ |
