Personal Information

Dr. Deeksha Tripathi

Assistant Professor
Department of Microbiology

MSc. (Microbiology; University of Delhi), PhD (Biotechnology; Jawaharlal Nehru University), PostDoctoral -IIT Delhi, Visiting Scientist- Neuroscience, Physiology, Pharmacology Department, University College London, UK, AMI Young Scientist Award, CSIR-JRF

deeksha.tripathi@curaj.ac.in

8851671620
  • Human Microbiome
  • Host-Pathogen interactions
  • Mycobacterium tuberculosis: dormancy and persistence
  • Drug Designing
  • Vaccine Development
  • AMI – YOUNG SCIENTIST AWARD 2015 (MEDICAL & VETENARY MICROBIOLOGY)
  • National Postdoctoral Fellowship DST- SERB 2016
  • DBT RESEARCH ASSOCIATESHIP AWARD 2015
  • ICMR International Travel Grant for ASM general meeting 2014 for poster presentation.
  • ASM 2014 Student Travel Grant for poster presentation.
  • Young Scientist Award (Women category) for oral presentation in National Symposium on Microbes in Health and Agriculture. (Under UGC resource networking) (MHA-2012), School of Life Sciences, JNU, New Delhi, India, 12-13 March 2012.
  • Awarded Best Title for the Abstract in ASM Virtual Workshop on Scientific Writing and Publishing (ASM 2012), KIIT University, Bhubaneswar, Odisha, India, November, 22 2012.
  • CSIR-JRF and SRF Senior research fellowship (2009-2014)
  • Monsanto Scholarship during MSc Microbiology (2007-2009).

My research work sprawls around tuberculosis pathogen Mycobacterium tuberculosis. During my Ph.D. research at Jawaharlal Nehru University, I gained a strong inclination in tuberculosis pathogenesis and gene regulation. My Ph.D. and postdoctoral research have been complimentary experiences. My research work includes study of chaperone like function of Cyclophilins (peptidyl prolyl isomerase) of Mycobacterium tuberculosis (Mtb) and I have extended my work on their immune modulatory potential. I have also been working on potential role of mycobacterial Ppiases in responding to host generated stresses like hypoxia and oxidative stress.

S. No. Authors Title of Article Journal/Conference Details Journal/Conference Publication Year
1 Kumar A#, Alam A#, Grover S#, Pandey S#, Tripathi D, Kumari M, Rani M, Singh A, Akhter Y, Ehtesham NZ, Hasnain SE Peptidyl-prolyl isomerase-B is involved in Mycobacterium tuberculosis biofilm formation and a generic target for drug repurposing-based intervention. Biofilms and Microbiomes. 84:147–157, IF = 4.128 #equal first author; DOI:10.1038/s41522-018-0075-0; (ISSN No 2055-5008) Journal 2019
2 Pandey S, Yadav B, Pandey A, Tripathi T, Khawary M, Kant S, Tripathi D Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future, , Biology; 9:141; doi:10.3390/biology9060141, IF=3.79; (ISSN: 2079-7737) Journal 2020
3 Tripathi D, Kant S, Pandey S, Ehtesham NZ Resistin in Metabolism, Inflammation and Diseases, The FEBS Journal, DOI: 10.1111/febs.15322, IF = 4.74, (ISSN: 1742-464X) Journal 2020
4 Pandey S, Kant S, Khawary M, Tripathi D Macrophages in Microbial Pathogenesis: Commonalities of Defense Evasion Mechanisms Infection and Immunity, DOI:10.1128/IAI.00291-21 (ISSN 0019-9567) Journal 2022
5 Khawary M, Rakshit R, Bahl A, Juneja P, Kant S, Pandey S, Tripathi D M.tb-Rv2462c of Mycobacterium tuberculosis Shows Chaperone-Like Activity and Plays a Role in Stress Adaptation and Immunomodulation Biology; 12: 69. DOI:10.3390/ biology12010069 Journal 2023
6 2. Hasnain SE, Ehtesham N Z, Tripathi D, Grover S, Kumar A, Alam A, Pandey S A medicament for the treatment of diseases by biofilm forming microorganisms PATENT Publication (USA, Application Number 16607061) Journal 2020
7 Pandey S, Kant S, Khawary M, Tripathi D Macrophages in Microbial Pathogenesis: Commonalities of Defense Evasion Mechanisms Infection and Immunity, DOI:10.1128/IAI.00291-21 (ISSN 0019-9567) Journal 2022

Kumar A#, Alam A#, Tripathi D, Rani M, Khatoon H, Pandey S, Ehtesham NZ, Hasnain SE (2018); Protein adaptations in extremophiles: An insight into extremophilic connection of mycobacterial proteome, Seminars in Cell and Developmental Biology, DOI: 10.1016/j.semcdb.2018.01.003, IF=6.6, (UGC Journal No 35747) (ISSN 1084-9521)    # Authors contributed equally.

 

Pandey S#, Tripathi D#, Khubaib M#, Kumar A, Shaikh J, Ehtesham NZ, Hasnain SE, (2017) Mycobacterium tuberculosis peptidyl-prolyl isomerases show immunogenicity, alter cytokine profile and aid in intraphagosomal survival, Frontiers in Infection and Cellular Microbiology, DOI: 10.3389/fcimb.2017.00038. # Authors contributed equally

Pandey S, Sharma A, Tripathi D, Kumar A, Khubaib M, Bhuwan M, Chaudhuri TK, Hasnain SE, Ehtesham NZ; (2016). Mycobacterial peptidyl-prolyl isomerases show chaperone like activity; in vitro and in vivo; Plos One , DOI10.1371/journal.pone.0150288

 

Tripathi D, Kant S, Garg R, Bhatnagar R (2015) Low expression level of glnA1 accounts for absence of cell wall associated poly-L-glutamate/glutamine in Mycobacterium smegmatis. Biochem Biophys Res Communications, 458:240-245. DOI:10.1016/j.bbrc.2015.01.079.

 

Garg R, Tripathi D, Kant S, Chandra H, Bhatnagar R, Banerjee N (2014). A conserved hypothetical protein Rv0574c is required for cell wall integrity and virulence of Mycobacterium tuberculosis. Infection and Immunity, 83:120-129. DOI:10.1128/IAI.02274-14.

 

Tripathi D, Chandra H, Bhatnagar R (2013) Poly-L-glutamate/glutamine synthesis in the cell wall of Mycobacterium bovis is regulated in response to nitrogen availability. BMC Microbiology, 13:226. DOI:10.1186/1471-2180-13-226.

 

Rahi A, Rehan M, Garg R, Tripathi D, Lynn AM, Bhatnagar R (2011) Enzymatic characterization of catalase from Bacillus anthracis and prediction of critical residues using information theoretic measure of relative entropy. Biochem Biophys Res Commun 411:88–95. DOI:10.1016/j.bbrc.2011.06.099.

 

Pandey S, Tripathi D, Nasreen Z Ehtesham, (2019) Resistin in metabolism, inflammation and disease (Under Review, Molecular Microbiology)

 

Rajni Garg, Rajesh Mani, Manish Gupta, Deeksha Tripathi, Harish Chandra, Rakesh Bhatnagar, Nirupama Banerjee; Importance of cell wall associated Poly-a-L-glutamine in the biology of pathogenic mycobacteria, Book chapter under review, Springer.

SERB International Research Experience (SIRE) (2022-2023) – 16 Lakhs: “Alzheimer's Disease: Methods for investigating protective effects in mouse brain of Mycobacterium indicus pranii, A saprophytic mycobacterium with immunomodulatory and Antitubercular properties”(File No: SIR/2022/000220).PI

DST SERB Intensification of Research in High Priority Area (IRHPA) Grant (2022-2027) 9.6 crores: Creation of a BSL-3 facility at CURAJ under Rajasthan Biocluster for infectious diseases, therapeutics and diagnostics (File no-IPA/2021/000196), Co-PI

DBT Biocare grant 2019-2022 -55 Lakhs, “Identifying the role of Mycobacterium indicus pranii (MIP) in activating host innate immune response for development of new intervention strategy to combat tuberculosis. PI

UGC Startup grant (2017-2019)-10 Lakhs, “Functional Characterization of FKBP type peptidyl-prolyl cis/ trans isomerase of M. tuberculosis for its role in stress response of the pathogen”. PI

Attended

  1. Invited Lecture on “Fungal disease the emerging threat to human health” on 29.05.21 at Govt. Nehru PG Collage, Rajnandgaon (C.G.)
  2. Participated in “One week faculty development program on Implementation of national educational policy 2020, Role of Faculty members of HEIs” conducted during 4-8 Nov, 2020 organized by Teaching learning center, Central University of Rajasthan.
  3. UGC sponsored Refresher course in the subject of Botany and Life Sciences at University of Lucknow from Dec 17-31, 2019.
  4. Invited Lecture on Transcriptomics: Analysis of gene at the Transcriptional Level, at Modern Biology with focus on infectious disease, at JH Institute of Molecular Medicine, Jamia Hamdard, New Delhi, India at Nov, Dec,14, 2019.
  5. Invited Lecture on “Biosensor: Current Trends” in the National workshop on Sensor Networks, Internet of Things and internet of Everything, on September 12, 2019 at Pachhunga University Collage, Mizoram, India.
  6. Participated in “Four week induction training program for teachers of higher education institutions (HEIs)” from 1-26 May, 2018 organized by Teaching Learning Centre, Central University of Rajasthan.
  7. Invited Talk on “Mycobacterium tuberculosis: New Insight into an old bug” on Aug 24, 2018 organized by Department of Botany, CMP Collage, University of Allahabad.
  8.  Invited Lecture on “Application of Microbiology in Agriculture and Industries” on August 23, 2018 at Department of Botany, CMP College, Allahabad.
  9. Participated in, Annual Herpesviruses: Pathogenesis and Cancer Symposium organized by Tumor virology program, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA on, June 23, 2017.
  10. Participated in The Noreen O'Neill Melanoma Research Symposium at The Wistar Institute, the cancer institute distinguished by National Cancer Institute, Philadelphia, PA, USA on June 5, 2017.
  11. Tripathi D, Kant S. Non-coding small RNA modulates stability of cry4A mRNA of Bacillus thuringiensis israelensis. Bacillus ACT (2015) The International Conference on Bacillus anthracis, B. cereus and B. thuringiensis, New Delhi, India, 27-31 October 2015.
  12. Tripathi D, Garg R, Kant S, Bhatnagar R. Comparative study of glnA1 promoter of Mycobacterium bovis and Mycobacterium smegmatis; its implications on poly-α-L-glutamine (PLG) synthesis in the cell wall of mycobacteria. 114th General Meeting, American Society for Microbiology (ASM 2014), Boston, Massachusetts, USA, 17-20 May 2014. 
  13. Garg R, Tripathi D, Kant S, Chandra H, Bhatnagar R, Banerjee N. A conserved hypothetical protein Rv0574c is required for cell wall integrity and virulence of Mycobacterium tuberculosis. 113th General Meeting, American Society for Microbiology (ASM 2013), Denver, Colorado, USA, 18-21 May 2013. 
  14. Tripathi D, Chandra H, Garg R, Kant S, Bhatnagar R. Comparative study of glnA1 promoter of Mycobacterium tuberculosis and Mycobacterium smegmatis; its implications on poly-α-L-glutamine (PLG) synthesis in the cell wall of mycobacteria. International Conference on Microbial World: Recent Innovation and Future Trends. 53rd Annual Conference of Association of Microbiologist of India (AMI), KIIT University, Bhubaneswar, Odisha, India, 22-25 November 2012. 
  15. Tripathi D, Chandra H, Garg R, Kant S, Bhatnagar R. Comparative study of glnA1 promoter of Mycobacterium bovis and Mycobacterium smegmatis; its implications in poly-α-L-glutamine (PLG) synthesis in the cell wall of mycobacteria. National Symposium on Microbes in Health and Agriculture. (Under UGC resource networking) (MHA-2012), School of Life Sciences, JNU, New Delhi, India, 12-13 March 2012 (Oral Presentation)- 1st prize for Young Scientist Award.
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