Personal Information

Dr. Ruchi Malik

Assistant Professor
Department of Pharmacy

Ph. D. from Punjab University, Chandigarh, Post-doctoral research: University of Florence (2013), Italy

ruchimalik1976@curaj.ac.in

  • Medicinal Chemistry
  • Chemical Biology
  • Drug Design
  • Neurodegeneration, Cancer
  • Ph. D. from Punjab University, Chandigarh,
  • Post-doctoral research: University of Florence (2013), Italy
  • Medicinal Chemistry
  • Chemical Biology
  • Drug Design
  • Neurodegeneration, Cancer
S. No. Authors Title of Article Journal/Conference Details Journal/Conference Publication Year
1 1
  • Sukanya, Choudhary, B. S., Mehta, P., Filipek, S., Malik, R. Identification of CNS compatible small molecules as Glycogen synthase kinase-3β (GSK-3β) inhibitors through structure-based virtual screening. Medicinal Chemistry Research, (Manuscript ID: MCRE-D-22-00104R2),Doi.org/10.1007/s00044-022-02912-z (Impact factor: 1.965) (Manuscript Accepted).
  • Bellver-Sanchis, A.*, Choudhary, B.S.*, Companys-Alemany, J., Sukanya, Ávila-López, P. A., Rodríguez, A. L. M., Jose Manuel Brea Floriani, J. M. B., Malik, R.,M Pallàs, M., Pérez, B.,Griñán-Ferré, C. Structure based virtual screening, in-vitro and in-vivo analysis revealed novel potent methyltransferase G9a inhibitors as prospective anti-Alzheimer’s agents. ChemMedChem. Doi.org/10.1002/cmdc.202200002 (Wiley, Impact factor: 3.466)
  • Choudhary, B. S., Sukanya, Mehta, P., Bach, S., Ruchaud, S., Robert, T.,  Josselin, B., Filipek, S., Malik, R. Discovery of thiazolidin-4-one analogue as Selective GSK-3β inhibitor through structure based virtual screening. Bioorganic and Medicinal Chemistry Letters, 2021, 52, 128375.Doi.org/10.1016/j.bmcl.2021.128375 (Impact Factor: 2.823)
  • Srivastava, S., Mehta, P., Sharma, O., Sharma, M., Malik, R. Computationally guided identification of Akt-3, a serine/threonine kinase inhibitor: Insights from homology modelling, structure-based screening, molecular dynamics and quantum mechanical calculations. Journal of Biomolecular Structure and Dynamics, 2020, 38 (14), 4179-4188.Doi.org/10.1080/07391102.2019.1675536.
  • Srivastava, S., Choudhary, B.S., Mehta, P., Sukanya, Sharma, M., &Malik, R. Molecular dynamic insights for PI3K-δ inhibition & structure guided identification of novel PI3K-δ inhibitors. Journal of Biomolecular Structure and Dynamics, 2019, 37(9), 2404-2414.Doi.org/10.1080/07391102.2018.1489304
  • Mishra, M., Kumar, P., Rajawat, J. S., Malik, R., Sharma, G., & Modgil, A. (2019). Nanotechnology: Revolutionizing the Science of Drug Delivery. Current pharmaceutical design. Doi: 10.2174/1381612825666190206222415 [Impact factor-2.757]
  • Kumar, P., Sharma, G., Gupta, V., Kaur, R., Thakur, K., Malik, R., Kumar, A., Kaushal, N., Katare, O.P. and Raza, K. (2019). Oral Delivery of Methylthioadenosine to the Brain Employing Solid Lipid Nanoparticles: Pharmacokinetic, Behavioral, and Histopathological Evidences. AAPS PharmSciTech, 20(2), 74. Doi: 10.1208/s12249-019-1296-0 [Impact factor-2.666]
  • Srivastava, S., Vengamthodi, A., Singh, I., Singh Choudhary, B., Sharma, M., Malik R.* Determination of comprehensive in silico determinants as a strategy for identification of novel PI3Kα inhibitors  (2019). Structural Chemistry Doi:  10.1007/s11224-019-01303-2 [Impact factor-2.019]
  • Mehta, P., Srivastava, S., Sharma, M., Malik R.* (2019) Discovery of novel chemotypes for competitive AMPA receptor antagonists as potential antiepileptic agents through structure-based virtual screening of natural products library. Structural Chemistry  Doi: 10.1007/s11224-018-1269-z [Impact factor-2.019]
  • Mehta, P., Srivastava, S., Sharma, M., Singh, I., & Malik, R.* (2018). Identification of chemically diverse GABAA agonists as potential anti-epileptic agents using structure-guided virtual screening, ADMET, quantum mechanics and clinical validation through off-target analysis. International journal of biological macromolecules, 119, 1113-1128. Doi: 10.1016/j.ijbiomac.2018.08.032 [Impact factor-3.909]
  • Piplani, P., Sharma, M., Mehta, P., & Malik, R.* (2018). N-(4-Hydroxyphenyl)-3, 4, 5-trimethoxybenzamide derivatives as potential memory enhancers: synthesis, biological evaluation and molecular simulation studies. Journal of Biomolecular Structure and Dynamics, 36(7), 1867-1877. Doi: 10.1080/07391102.2017.1336943 [Impact factor-3.107]
  • Kumar P., Sharma G., Gupta V., Kaur R., Thakur K., Malik R., Kumar A., Kaushal N., Raza K. (2018). Preclinical Explorative Assessment of Dimethyl Fumarate-Based Biocompatible Nanolipoidal Carriers for the Management of Multiple Sclerosis. ACS Chemical Neuroscience. 9(5) Doi: 10.1021/acschemneuro.7b00519.[Impact factor-3.883] Cover page
  • Srivastava, S., Singh Choudhary, B., Mehta, P., Sukanya, Sharma, M., & Malik, R.* (2018). Molecular dynamics insights for PI3K-δ inhibition & structure guided identification of novel PI3K-δ inhibitors. Journal of Biomolecular Structure and Dynamics, 1-11. Doi: 10.1080/07391102.2018.1489304 [Impact factor-3.107]
  • Kumar P., Sharma G., Kumar R., Ruchi M., Singh B., Katare O. P., Raza K. 2017. Stearic Acid-based, Systematically Designed Oral Lipid Nanoparticles for Enhanced Brain Delivery of Dimethyl Fumarate. Nanomedicine (Lond.). 12(23, 2607-2621 doi: 10.2217/nnm-2017-0082. [Impact factor-4.727]
  • Mehta, P., Srivastava, S., Choudhary, B. S., Sharma, M., &Malik, R.* (2017). Probing voltage sensing domain of KCNQ2 channel as a potential target to combat epilepsy: a comparative study. Journal of Receptors and Signal Transduction, 37(6), 578-589. (Impact Factor: 1.614)
  • Piplani, P.*, Sharma, M., Mehta, P., &Malik, R.* (2017). N-(4-Hydroxyphenyl)-3, 4, 5-trimethoxybenzamide derivatives as potential memory enhancers: Synthesis, biological evaluation and molecular simulation studies. Journal of Biomolecular Structure and Dynamics, 1-11. (Impact Factor: 3.123)
  • Chander, S., Pandey, R. K., Penta, A., Choudhary, B. S., Sharma, M., Malik, R., Prajapati, V. K., &Murugesan, S. (2017). Molecular docking and molecular dynamics simulation based approach to explore the dual inhibitor against HIV-1 reverse transcriptase and Integrase. Combinatorial Chemistry &High throughput Screening, 20(8), 734-746. (Impact Factor: 0.952)
  • Chaudhary, S., Gothwal, A., Khan, I., Srivastava, S., Malik, R., & Gupta, U. (2017). Polypropyleneimine and polyamidoamine dendrimer mediated enhanced solubilization of bortezomib: Comparison and evaluation of mechanistic aspects by thermodynamics and molecular simulations. Materials Science and Engineering: C, 72, 611-619. (Impact Factor: 4.164)
  • Kumar, P., Sharma, G., Kumar, R., Malik, R., Singh, B., Katare, O. P., & Raza, K. (2017). Vitamin-derived nanolipoidal carriers for brain delivery of dimethyl fumarate: a novel approach with preclinical evidence. ACS Chemical Neuroscience, 8(6), 1390-1396. (Impact Factor: 3.883)
  • Kumar, P., Kumar, R., Singh, B., Malik, R., Sharma, G., Chitkara, D., Katare, O. P.& Raza, K. (2017). Biocompatible phospholipid-based mixed micelles for tamoxifen delivery: Promising evidences from in-vitro anticancer activity and dermatokinetic studies. AAPS PharmSciTech, 18(6), 2037-2044. (Impact Factor: 2.451)
  • Kumar, P., Sharma, G., Kumar, R., Singh, B., Malik, R., Katare, O. P., & Raza, K. (2016). Promises of a biocompatible nanocarrier in improved brain delivery of quercetin: Biochemical, pharmacokinetic and biodistribution evidences. International Journal of Pharmaceutics, 515(1-2), 307-314. (Impact Factor: 3.649)
  • Kumar, P., Sharma, G., Kumar, R., Malik, R., Singh, B., Katare, O. P., & Raza, K. (2017). Enhanced brain delivery of dimethyl fumarate employing tocopherol-acetate-based nanolipidic carriers: evidence from pharmacokinetic, biodistribution, and cellular uptake studies. ACS Chemical Neuroscience, 8(4), 860-865. (Impact Factor: 3.883)
  • Malik, R.*, Choudhary, B. S., Srivastava, S., Mehta, P., & Sharma, M. (2017). Identification of novel acetylcholinesterase inhibitors through e-pharmacophore-based virtual screening and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics, 35(15), 3268-3284. (Impact Factor: 3.123)
  • Malik, R.*, Mehta, P., Srivastava, S., Choudhary, B. S., & Sharma, M. (2017). Structure-based screening, ADMET profiling, and molecular dynamic studies on mGlu2 receptor for identification of newer antiepileptic agents. Journal of Biomolecular Structure and Dynamics, 35(16), 3433-3448. (Impact Factor: 3.123)
  • Malik, R.*, Bunkar, D., Choudhary, B. S., Srivastava, S., Mehta, P., & Sharma, M. (2016). High throughput virtual screening and in silico ADMET analysis for rapid and efficient identification of potential PAP248-286 aggregation inhibitors as anti-HIV agents. Journal of Molecular Structure, 1122, 239-246. (Impact Factor: 1.753)
  • Malik, R.*, Mehta, P., Srivastava, S., Choudhary, B. S., & Sharma, M. (2017). Pharmacophore modeling, 3D-QSAR, and in silico ADME prediction of N-pyridyl and pyrimidine benzamides as potent antiepileptic agents. Journal of Receptors and Signal Transduction, 37(3), 259-266. (Impact Factor: 1.614)
  • Malik, R.*, Gupta, R., Srivastava, S., Choudhary, B. S., & Sharma, M. (2017). Design, synthesis and biological evaluation of selected 3-[3-(amino) propoxy] benzenamines as acetylcholinesterase inhibitors. Journal of Biomolecular Structure and Dynamics, 35(11), 2382-2394. (Impact Factor: 3.123)
  • Raza, K., Kumar, N., Misra, C., Kaushik, L., Guru, S. K., Kumar, P., Malik, R., Bhushan, S., &Katare, O. P. (2016). Dextran-PLGA-loaded docetaxel micelles with enhanced cytotoxicity and better pharmacokinetic profile. International Journal of Biological Macromolecules, 88, 206-212. (Impact Factor: 3.671)
  • Srivastava, S., Choudhary, B. S., Sharma, M., &Malik, R.* (2016). Pharmacophore modeling and 3D-QSAR studies of galloylbenzamides as potent P-gp inhibitors. Medicinal Chemistry Research, 25(6), 1140-1147. (Impact Factor: 1.277)
  • Pandey, R. K., Kumbhar, B. V., Srivastava, S., Malik, R., Sundar, S., Kunwar, A., &Prajapati, V. K. (2016). Febrifugine analogues as Leishmaniadonovanitrypanothione reductase inhibitors: binding energy analysis assisted by molecular docking, ADMET and molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics, 35(1), 141-158. (Impact Factor: 3.123)
  • Pandey, R. K., Narula, A., Naskar, M., Srivastava, S., Verma, P., Malik, R., Shah, P., &Prajapati, V. K. (2016). Exploring dual inhibitory role of febrifugine analogues against Plasmodium utilizing structure-based virtual screening and molecular dynamic simulation. Journal of Biomolecular Structure and Dynamics, 35(4), 791-804. (Impact Factor: 3.123)
  • Kumar, P., Raza, K., Kaushik, L., Malik, R., Arora, S., & Prakash Katare, O. (2016). Role of colloidal drug delivery carriers in taxane-mediated chemotherapy: a review. Current Pharmaceutical Design, 22(33), 5127-5143. (Impact Factor: 2.611)
  • Raza, K., Thotakura, N., Kumar, P., Joshi, M., Bhushan, S., Bhatia, A., Kumar, V., Malik, R., Sharma, G., Guru, S. K. &Katare, O. P. (2015). C60-fullerenes for delivery of docetaxel to breast cancer cells: a promising approach for enhanced efficacy and better pharmacokinetic profile. International Journal of Pharmaceutics, 495(1), 551-559. (Impact Factor: 3.649)
  • Guandalini, L., Martino, M. V., Mannelli, L. D. C., Bartolucci, G., Melani, F., Malik, R., Dei, S., Floriddia, E., Manetti, D., Orlandi, F., Teodori, E., Gherlardini, C., Romanelli, M. N. (2015). Substituted piperazines as nootropic agents: 2-or 3-phenyl derivatives structurally related to the cognition-enhancer DM235. Bioorganic &Medicinal Chemistry Letters, 25(8), 1700-1704. (Impact Factor: 2.454)
  • Gupta, R., Sharma, M., &Malik, R.* Cognition Enhancers: A Review. (2015). Journal of Medical and Pharmaceutical Innovation, 2(7), 1-13.
  • Malik, R* (2015). Design of PAP (248-286) aggregation inhibitors as potential anti-HIV agents using molecular docking based virtual screening. Asian Journal of Pharmaceuticeutics, 1-25. (Impact Factor: 0.460)
  • Malik, R.*, Gupta, R., Shukla, V., & Sharma, M. (2014). Synthesis, characterization and Evaluation of some potent memory enhancing agents derived from p-cresol. Journal of International Academic Research for multidisciplinary, 2(7), 519-526. (Impact Factor: 2.417)
  • Raza, K., Kumar, P., Ratan, S., Malik, R., & Arora, S. (2014). Polymorphism: The Phenomenon Affecting the Performance of Drugs. SOJ Pharmacy & Pharmaceutical Sciences, 1(2), 1-10.
  • Raza, K., Kumar, M., Kumar, P., Malik, R., Sharma, G., Kaur, M., &Katare, O. P. (2014). Topical delivery of aceclofenac: challenges and promises of novel drug delivery systems. BioMed Research International, 1-11. (Impact Factor: 2.476)
  • Malik, R.*, Gupta, R., Krishna, A., Bunkar, D., & Sharma, M. (2014). Synthesis, Characterization and Evaluation of Selected 3-Nitrophenol Derivatives as Potential Cognition Enhancers. International Journal of Drug Design and Discovery, 5(2), 1318-1325.
  • Nalwaya, R., Sahai, A., Chander, S., Sharma, M., Malik, R., &Sarsodia, G. (2013). Synthesis, characterization, and pharmacological evaluation of benzothiopyran derivatives as a novel class of calcium channel blockers. Medicinal Chemistry Research, 22(5), 2188-2195. (Impact Factor: 1.27)
  • Piplani, P., Malik, R., Kaur, B., &Kaplish, A. (2012). Synthesis and pharmacological evaluation of some new naphthol derived aryloxy derivatives as cognition enhancers. Medicinal Chemistry Research, 21(8), 1771-1779. (Impact Factor: 1.058)
  • Gurumoorthy, A., Gopalsamy, V., Piplani, P., &Malik, R. (2011). N-[4-(2-Morpholinoethoxy) phenyl] acetamide monohydrate. ActaCrystallographica Section E: Structure Reports Online, 67(2), o262-o262. (Impact Factor: 0.45)
  • Daniel, V., Shrivastva, K., Kunwar, P. S., Malik, R., &Barve, A. (2009). Synthesis and anti-amnesic activity of some new 2-naphtholoxy derivatives. Journal of Global Pharma Technology, 1(1), 45-50.
  • Malik, R., Sangwan, A., Saihgal, R., Paul Jindal, D., &Piplani, P. (2007). Towards better brain management: nootropics. Current medicinal chemistry, 14(2), 123-131. (Impact factor: 4.94)
  • Sundar, T. V., Parthasarathi, V., Lang, H., Malik, R., &Piplani, P. (2006). N-[4-(Morpholinocarbonylmethoxy) phenyl] acetamide monohydrate: a potential antiamnesic agent. ActaCrystallographica Section E: Structure Reports Online, 62(5), 01874-01876. (Impact Factor: 0.45)
  • Sundar, T. V., Parthasarathi, V., Lang, H., Malik, R., &Piplani, P. (2006). 2-[4-(Acetamido) phenoxy]-N, N-dimethylacetamide: a potential anti-amnesic agent. ActaCrystallographica Section E: Structure Reports Online, 62(2), 0443-0445. (Impact Factor: 0.45)
  • Sundar, T. V., Parthasarathi, V., Walfort, B., Lang, H., Piplani, P., &Malik, R. (2005). N-[4-(Pyrrolidin-1-ylcarbonylmethoxy) phenyl] acetamide. ActaCrystallographica Section E: Structure Reports Online, 61(9), 02868-02870. (Impact Factor: 0.45)
  • Piplani, P., Jindal, D. P., Gupta, P., Malik, R., Tiwari, H., & Kulkarni, S. K. (2004). 2-Naphthyloxy derivatives of N, N-substituted acetamides: synthesis and pharmacological evaluation. Indian Journal of Pharmaceutical Sciences, 66(5), 653-658. (Impact Factor: 0.296)
  • Thamotharan, S., Parthasarathi, V., Malik, R., Jindal, D. P., Piplani, P., & Linden, A. (2003). 2-(2-Naphthyloxy) acetate derivatives. I. A new class of antiamnesic agents. ActaCrystallographica Section C: Crystal Structure Communications, 59(8), 0422-0425. (Impact Factor: 0.45)
  • Thamotharan, S., Parthasarathi, V., Malik, R., Jindal, D. P., Piplani, P., & Linden, A. (2003). 1-[2-(4-Nitrophenoxy) acetyl] pyrrolidin-2-one: an antiamnesic agent. ActaCrystallographica Section C: Crystal Structure Communications, 59(9), 0514-0515. (Impact Factor: 0.45)

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Sponsored Projects:

  • Project Title: Design, synthesis and biological evaluation of some novel aryloxy derivatives as potential AChE inhibitors

Project Status: Completed; Duration: 2 Years(From July 18, 2014 to July 17, 2016)

Total Budget: 6 Lakhs; Funding Agency: University Grants Commission, India

Type: National

  • Project Title: Computational studies, synthesis and biological evaluation of novel pyrimidin-4-amine derivatives, as multikinase inhibitors

Project Status: Ongoing; Duration: 3 Years (From August 10, 2016 to August 09, 2019)

Total Budget: 7.68 Lakhs; Funding Agency: DST-Rajasthan, India

Type: National

 

  • Project Title: Targeted, Safe and Effective Delivery of Doxorubicin to Breast Cancer by Means of Strategically Design

Project Status: Ongoing; Duration: 3 Years (February 15, 2017 to February 14, 2020)

Total Budget: 48 Lakhs; Funding Agency: Department of Biotechnology, India

Type: National

 

  • Project Title: Design, synthesis and biological evaluations of β-secretase inhibitors as anti-Alzheimer’s agents

Project Status: Ongoing; Duration: 2 Years (June 07, 2017 to June 06, 2019)

Total Budget: 19.84 Lakhs; Funding Agency: Department of Science & Technology-India and Ministry of Science & Higher Education –Poland (DST-Indo-Poland Project)

Type:Inter national

  • Project Title: Design, synthesis and biological evaluation of GSK-3β inhibitors as cognition enhancers

Project Status: Approved; Duration: 2 Years

Total Budget: Funding Awaited; Funding Agency: Department of Science & Technology-India and German Academin Exchange Service (DST-DAAD Project)

Type:Inter national

 

Consultancy projects:

  • Project Title: Quality Control Protocol Development of herbal formulation DIANO and characterization of isolated alkaloids

Project Status: Completed; Duration: 2 Years; Total Budget: 2 Lakhs

Funding Agency: SIRO-DSIR and Padmavati Group of Companies

 

  1. Project Title: Development of a process for production of sugar/oligosachharide free phosphatidylcholine

Project Status: Completed; Duration: 1 Year; Total Budget: 10 Lakhs

Funding Agency: DST TIFAC-CORE and Sonic Biochem Extractions Ltd.

 

  • Project Title: Development of a cost economic process for separation and purification of phytosterol to meet inter

Project Status: Completed; Duration: 2 Years; Total Budget: 20 Lakhs

Funding Agency: DST TIFAC-CORE and Sonic Biochem Extractions Ltd.

 

  • Project Title: Development of a process for conversion of phosphatidylcholine to phosphatidylserine

Project Status: Completed; Duration: 3 Years; Total Budget: 30 Lakhs

Funding Agency: DST TIFAC-CORE and Sonic Biochem Extractions Ltd.

  • Project Title: Devise a method to convert phytosterol to water dispersible phytosterol

Project Status: Completed; Duration: 1 Year; Total Budget: 10 Lakhs

Funding Agency: DST TIFAC-CORE and Sonic Biochem Extractions Ltd.

  • Project Title: To develop and evaluate liposomal drug delivery system by using lecichomax70 (Soya phosphatidylcholine)

Project Status: Completed; Duration: 3 Years; Total Budget: 30 Lakhs

Funding Agency: DST TIFAC-CORE and Sonic Biochem Extractions Ltd.

 

  • Project Title: Yield enhancement of PNT bromination

Project Status: Completed; Duration: 2 Years; Total Budget: 2 Lakhs

Funding Agency: SIRO-DSIR and Saurav Chemicals Ltd.