Personal Information

Dr. Easwar S.

Associate Professor, Dean and Head

Ph. D. - National Chemical Laboratory (NCL) Pune, Post-doctoral Research Associate - University of Bologna, Italy

Broad Research Interests:

  • Organocatalysis
  • Asymmetric Synthesis
  • Morita-Baylis-Hillman Reaction and Applications
  • Green Synthetic Methodologies
  • Natural Product Synthesis


Academic Background and Experience:

>> B.Sc. (1998): Ramakrishna Mission Vivekananda College, University of Madras

>> M.Sc. (2000): Department of Chemistry, University of Pune

>> Ph.D (2006).: National Chemical Laboratroy (NCL) Pune

Supervisor: Dr. N. P. Argade; thesis work involved the total synthesis of anhydride and alkaloid based natural products, and also enzymatic resolution to access enantiomerically enriched synthons and key intermediates

2006-'08: Post-Doctoral Research Fellow at the University of Bologna, Italy

Mentor: Prof. Claudio Trombini; worked in the area of asymmetric organocatalysis; developed highly efficient proline-based organocatalysts that offered excellent stereocontrol in the direct asymmetric aldol reaction under aqueous biphasic conditions.

2008-'11: Senior Research Scientist (R & D), Sai Advantium Pharma Ltd. Pune

2011-'19: Assistant Professor, Department of Chemistry, Central University of Rajasthan

Since June 2019: Associate Professor, Department of Chemistry, Central University of Rajasthan


  • June 2024: Hearty Congratulations to Sachin Sharma on the submission of Ph.D. Thesis!
  • Hearty Congratulations to Sachin Sharma and Dr. Ajit Jha for the recent publication in Org. Chem. Front.
  • Hearty Congratulations to Dr. Rajkiran Kumari, Dr. Ajit Jha and Mr. Akram Khan for the recent publication in J. Org. Chem.
  • Hearty Congratulations to Dr. Rajkiran Kumari who has joined the group of Prof. A. K. Ghosh at Purdue University, USA as a Post-Doctoral Fellow from Apr 2024
  • Two research scholars, Kiran Kumari and Rajkiran Kumari recently defended their Ph.D. Thesis (March 2024). Congratulations to the new Doctorates!
  • Dr. Kiran Kumari has joined SRF Ltd, Bhiwadi as a Research Scientist (Sep 2023)
  • ES was awarded the "Professor D. K. Banerjee Memorial Lecture Awarad" by the Department of Chemistry, Indian Institute of Science (IISc) Bangalore, "for his notable contributions in developing methods in organic synthesis" in April 2023. Congratulations to the group and alumni for all the hard work.
  • ES was recently sanctioned the prestigious MoE-STARS project, which is coordinated by IISc Bangalore. Congratulations to the group and alumni for all the hard work.


Our Research Group works in the following broad domains:

>> Investigating the Morita-Baylis-Hillman (MBH) reaction and applications of MBH adducts:

- Here, our group works on exploring the MBH ketone, obtained by the oxidation of the MBH adduct, in various transformations and toward the development of new synthetic methodologies​

Some of the novel transformations achieved in this regard include:

(i) The synthesis of N'-alkyl substituted benzohydrazides, which have a huge potential as insecticides; this was achieved by insertion of a hydrazine into the MBH ketone, featuring the formation of 2 new C-N bonds and accompanied by cleavage of a C-C bond.

(ii) A diamine-mediated degradative dimerisation of MBH ketones leading to the formation of methylene-bridged bis-1,3-dicarbonyl adducts (with the loss of a 1-carbon unit in the process).

Recent significant publications in the area:

  1.  A retro-Mannich mediated transformation of Morita–Baylis–Hillman ketones to saturated imidazo[1,2-a]pyridines; S. Sharma, A. K. Jha and S. EaswarOrg. Chem. Front. 2024, 11, 3137-3150 (DOI: 10.1039/D4QO00352G)
  2. Mechanistic Investigations on the Interaction of Morita−Baylis−Hillman Ketones with 2‑Aminothiophenol; R. Kumari, A. K. Jha, A. G. H. Khan and S. EaswarJ. Org. Chem. 2024, 89, 7263-7269 (DOI: 10.1021/acs.joc.3c02993)
  3. Acyl Transfer Driven Rauhut–Currier Dimerization of Morita–Baylis–Hillman Ketones; R. Kumari, A. K. Jha, S. Goyal, R. Maan, S. R. Reddy and S. Easwar, J. Org. Chem. 2023, 88, 2023-2033 (DOI: 10.1021/acs.joc.2c02244)
  4. Synthesis of 2,2-Disubstituted Dihydro-1,4-benzothiazines from Morita−Baylis−Hillman Ketones by an Oxidative Cyclization, A. K. Jha, R. Kumari and S. EaswarJ. Org. Chem. 2022, 87, 5760-5772 (DOI: 10.1021/acs.joc.2c00087)
  5. Diamine-Mediated Degradative Dimerisation of Morita-Baylis-Hillman Ketones; A. K. Jha, A. Kumari and S. EaswarChem. Commun. 2020, 56, 2949-2952 (DOI: 10.1039/c9cc10068g)

>> Asymmetric Catalysis - focused primarily on:

- Design of proline-based organocatalysts for asymmetric transformations

- Development of bifunctional organocatalysts for enantioselective cascade cyclisations targeted toward the construction of fused and bridged ring systems

Some of the recent highlights from our group on organocatalysis include:

(i) Investigation of the synergistic organocatalytic model for the asymmetric aldol reaction by design of a urea-tagged proline catalyst

(ii) Studies on "through bond" and "through space" proximity of an ion-tag to the reaction site of a proline mediated aldol addition

Recent publications in the area:

  1. Cooperative assistance of a sulfonamide in a proline-mediated direct asymmetric aldol addition; K. Kumari, M. Bhati, R. S. Madhukar, A. G. H. Khan, P. Janjani, S. R. Reddy and S. EaswarNew J. Chem. 2023, 47, 17042-17050 (DOI: 10.1039/d3nj02685j)
  2. Proline-Histidine Dipeptide: A Suitable Template for Generating Ion-tagged Organocatalysts for the Asymmetric Aldol Reaction; H. Inani, A. Singh, M. Bhati, K. Kumari, A. S. Kucherenko, Sergei G. Zlotin and S. Easwar, Synthesis 2021, 53, 2702-2712 (DOI: 10.1055/a-1477-4871)
  3. Probing the Synergistic Catalytic Model: A Rationally Designed Urea-Tagged Proline Catalyst for the Direct Asymmetric Aldol Reaction; M. Bhati, K. Kumari and S. Easwar, J. Org. Chem. 2018, 83, 8225-8232 (DOI: 10.1021/acs.joc.8b00962)
  4. Exploring "Through-Bond" Proximity between the Ion-Tag and Reaction Site of an Imidazolium-Proline Catalyst for the Direct Asymmetric Aldol Reaction; M. Bhati, S. Upadhyay and S. Easwar, Eur. J. Org. Chem. 2017, 1788-1793 (DOI: 10.1002/ejoc.201700021)

    S. No. Authors Title of Article Journal/Conference Details Journal/Conference Publication Year


      Ongoing Projects:

      • MoE - STARS (STARS2/2023-1017) - Exploring Cooperatively Assisted and Conformationally Constrained Bifunctional Organocatalysts for Enantioselective Mannich and Michael Addition Reactions 2023-'26
      • SERB - CRG CRG/2022/008471 - Investigation of Diverse Reactivity Patterns in Morita–Baylis–Hillman Ketones to access Biologically Significant Heterocyclic Scaffolds 2023-'26

      International Collaborative Research Projects carried out:

      • DST – Academy of Finland Collaborative Project – “Studies on the Asymmetric Mannich and Michael Addition Reactions Catalyzed by a Folding Bifunctional Organocatalyst”; Carried out in collaboration with and in the laboratory of Prof. Petri Pihko, University of Jyvaskyla, Finland­
      • Indo-Russian (DST-RFBR) Collaborative Project - "Synthesis and studies on catalytic performance of novel ion-tagged recyclable chiral organocatalysts generated from suitable dipeptides"; Russian collaborator: Prof. Sergei Zlotin, Zelinsky Institute of Organic Chemistry, Moscow

      Other completed projects:

      • UGC sponsored project entitled "Studies towards the total synthesis of protoberberine based natural products"
      • CSIR (EMR): Design of Novel Bifunctional Amine-Urea/Thiourea Catalysts for Asymmetric C-C Bond Forming Applications 2018-'21
      • SERB (CRG)Studies on the organocatalytic enantioselective construction of tetrahydroxanthenones 2019-'22


      Invited Talks / Presentations:

      Talks recently delivered at:

      • Indian Institute of Science (IISc) Bangalore
      • Central University of Jammu
      • IISER Bhopal
      • University of Jyvaskyla, Finland
      • Karolinska Institute, Stockholm, Sweden
      • University of Bologna, Italy

      Invited talks at conferences / symposia:

      • "Prof. D. K. Banerjee Memorial Lecture" at Indian Institute of Science, Bangalore, Apr 2023
      • International Conference on "Recent Advances in Chemical Sciences" at Central University of Jammu, Nov 2022
      • "Interactions 2022" Symposium at IISER Bhopal, Mar 2022
      • Expert Lectures in the Workshop on “Spectroscopic Techniques for Materials Characterization”, MNIT Jaipur, Jan 2021
      • Invited Lecture in the FDP organized by Govt. Dungar College, Bikaner in association with Directorate College Education, Jaipur, under "Gyan Ganga" initiative, Jan 2021
      • National Conference on Emerging Trends in Chemical Sciences (ETCS-2019), Central University of Jammu, Mar 2019
      • International Conference on Chemical and Biological Sciences in Drug Discovery (IC-CBSDD-2019), Berhampur University, Mar 2019
      • International Conference on Recent Developments in Chemical Research (RDCR-2019), IIS University Jaipur, Feb 2019
      • International Conference on Advancing Green Chemistry: Building a Sustainable Tomorrow, Delhi University, Oct 2017
      • National Conference on Chirality, M. S. University of Baroda, Nov 2017
      • Contemporary Facets in Organic Synthesis, Indian Institute of Technology Roorkee, Dec 2017
      • National Symposium on Recent Trends in Eco-friendly Chemistry (RTEC-2016), Central University of Haryana, Sep 2016
      • National Conference on Organic Chemistry in Sustainable Development (OCSD-2016), BITS, Pilani, Aug 2016
      • National Seminar on Recent Trends in Chemical Research (NSRTCR-2016), JNV University, Jodhpur, Feb 2016
      • National Conference on Recent Advances in Chemical Sciences (RAICS-2015), MNIT Jaipur, Aug 2015
      • International Conference on New Emerging Trends in Chemistry, IIS University Jaipur, India, March 2013