Personal Information

Dr. Umesh Gupta

Associate Professor

M. Pharm., Ph.D. (Dr. H. S. Gour University, Sagar, India),Postdoc (2012-2013): South Dakota State University, USA

umeshgupta@curaj.ac.in

  • Pharmaceutics
  • Macromolecular drug delivery and targeting
  • Solubilization
  • Nanotechnology in drug/gene delivery

M.Pharm. Semester I

MPH103T Modern Pharmaceutics  
MPH104T Cosmetics and Cosmeceuticals
MPH106S Pharmaceutics Lab.-II
M.Pharm. Semester II

MPH201T Advanced Pharmacokinetics and Biopharmaceutics
MPH202T Computer-aided Drug Delivery Systems
MPH203T Molecular Pharmaceutics (Nano Tech and Targeted DDS)
MPH204T Basic Molecular Biology
MPC205P Pharmaceutical Chemistry Lab
MPH206S Seminar

M.Pharm. Semester III

MPH302JC Journal Club

MPH303PP Proposal Presentation

MPH304RW Research Work

Dendrimer Mediated Drug Targeting

Dendrimers are hyperbranched, monodispersed, three-dimensional macromolecules of nanometric size. PAMAM dendrimers are the most explored and potential dendrimeric nanocarriers for effective drug delivery in the management of diseases such as Alzheimer's disease, glioblastoma, cancer, etc.

Alzheimer's Disease

  • Vitamin-C Decorated PEGylated PAMAM Dendrimers for Effective Inhibition of Amyloid Aggregation and Improved In vivo Pharmacokinetics. Journal of Drug Delivery Science and Technology. 2023; 89(105058): 01-17. 

  • Lactoferrin Coupled Lower Generation PAMAM Dendrimers for Brain Targeted Delivery of Memantine in Aluminum-Chloride-Induced Alzheimer’s Disease in Mice. Bioconjugate Chemistry. 2019;30(10):2573-2583. 

  • Behavioral and Biochemical Implications of Dendrimeric Rivastigmine in Memory-Deficit and Alzheimer’s Induced Rodents. ACS Chemical Neuroscience. 2019;10(8):3789-3795. 

  • Dendrimer Donepezil Conjugates for Improved Brain Delivery and Better in Vivo Pharmacokinetics. ACS Omega. 2019;4(3):4519−4529. 

  • Boosted Memory and Improved Brain Bio-availability of Rivastigmine: Targeting Effort to Brain using Covalently Tethered Lower Generation PAMAM Dendrimers with Lactoferrin. Molecular Pharmaceutics. 2018;15(10):4538-4549. 

Glioblastoma Multiforme

  • Angiopep-2 Grafted PAMAM Dendrimers for the Targeted Delivery of Temozolomide: In-vitro and In-vivo Effects of PEGylation in the Management of Glioblastoma Multiforme. ACS Biomaterials Science & Engineering. 2023; 9(7): 4288–4301. 

  • Chitosan Engineered PAMAM Dendrimers as Nanoconstructs for the Enhanced Anti-cancer Potential and Improved in vivo Brain Pharmacokinetics of Temozolomide. Pharmaceutical Research. 2018;35(9):01-14.

Cancer

  • Lipid-Dendrimer Nanohybrid System or Dendrosomes: Evidences of Enhanced Encapsulation, Solubilization, Cellular Uptake and Cytotoxicity of Bortezomib. Applied Nanoscience. 2020;10:4049-4062.

  • PEGylated Dendrimer Mediated Delivery of Bortezomib: Drug Conjugation versus Encapsulation. International Journal of Pharmaceutics. 2020;584:11938.

Polymeric Nanoconjugates in Drug Targeting

Polymeric nanoconjugates have proven to be a potential candidate for drug delivery in managing breast cancer.

  • Sialic Acid Engineered Prodrug Nanoparticles for Co-delivery of Bortezomib and Selenium in Tumor Bearing Mice. Bioconjugate Chemistry. 2023; 34(9): 1528–1552. 

  • Biodegradable Nanoparticulate Co-Delivery of Flavonoid and Doxorubicin: Mechanistic Exploration and Evaluation of Anticancer Effect In Vitro and In Vivo. Biomaterials and Biosystems. 2021; 3(100022):01-15. 

  • Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo. ACS Applied Bio Materials. 2020;3(11):7789-7799. 

  • HPMA-PCL Polymeric Micelles in Co-delivery of Proteasome Inhibitor and Polyphenol: Exploration of Synergism or Antagonism. Molecular Pharmaceutics. 2023; 20(1): 524–544. 

  • Sialic Acid Conjugated Chitosan Nanoparticles: Modulation to Target Tumour Cells and Therapeutic Opportunities AAPS PharmSciTech. 2022; 23(10):01-16. ​

S. No. Authors Title of Article Journal/Conference Details Journal/Conference Publication Year
1 Sarita Rani, Avinash Gothwal, Pawan K. Pandey, Pravin Pachouri, Umesh D. Gupta, Devendra Singh Chauhan, Umesh Gupta* HPMA-PLGA Based Nanoparticles for Effective in Vitro Delivery of Rifampicin Pharmaceutical Research. 36:19 Journal 2019
2 Avinash Gothwal, Kartik N Nakhate, Amit Alexander, Ajazuddin, Umesh Gupta* Boosted Memory and Improved Brain Bio-availability of Rivastigmine: Targeting Effort to Brain using Covalently Tethered Lower Generation PAMAM Dendrimers with Lactoferrin Molecular Pharmaceutics. 15(10):4538-4549 Journal 2018
3 Iliyas Khan, Avinash Gothwal, Ankur Kaul, Rashi Mathur, Anil K Mishra, Umesh Gupta* Radiolabeled PLGA Nanoparticles for Effective Targeting of Bendamustine in Tumor Bearing Mice Pharmaceutical Research. 35:200 Journal 2018
4 Sarita Rani, Avinash Gothwal, Iliyas Khan, Pravin Pachouri, Umesh D. Gupta, Devendra Singh Chauhan, Umesh Gupta* Smartly Engineered PEGylated Di-block Nanopolymeric Micelles: Duo Delivery of Isoniazid and Rifampicin against Mycobacterium Tuberculosis AAPS PharmSciTech. 19(7):3237-3248 Journal 2018
5 Pawan Pandey, Ashok Sharma, Sarita Rani, Gaurav Mishra, Gopal Kandasamy, Ajit Patra, Monika Rana, Anuj Sharma, Awesh Yadav, Umesh Gupta* MCM-41 Nanoparticles for Brain Delivery: Better Choline-Esterase and Amyloid Formation Inhibition with Improved Kinetics ACS Biomaterials Science & Engineering. 4:2860-2869 Journal 2018
6 Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G. Antimisiaris, Nobuhito Hamano, Shyh-Dar Li, Mahavir Chougule, Sunday A. Shoyele, Umesh Gupta, Ajazuddin, Amit Alexander Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region Expert Opinion on Drug Delivery. 15(6):589-617 Journal 2018
7 Avinash Gothwal, Iliyas Khan, Pramod Kumar, Kaisar Raza, Ankur Kaul, Anil Mishra, Umesh Gupta* Bendamustine-PAMAM Conjugates for the Improved Apoptosis, Efficacy and in vivo Pharmacokinetics: A Sustainable Delivery Tactic Molecular Pharmaceutics. 15:2084-2097 Journal 2018
8 Ashok Kumar Sharma, Lokesh Gupta, Hitesh Kumar, Arem Qayum, Shashank K. Singh, Karthik Nakhate, Ajazuddin and Umesh Gupta* Chitosan Engineered PAMAM Dendrimers as Nanoconstructs for the Enhanced Anti-cancer Potential and Improved in vivo Brain Pharmacokinetics of Temozolomide Pharmaceutical Research. 35(9):1-14 Journal 2018
9 Prashant Kesharwani, Avinash Gothwal, Arun K. Iyer, Keerti Jain, Manish K. Chourasia and Umesh Gupta Dendrimer nanohybrid carrier systems: an expanding horizon for targeted drug and gene delivery Drug Discovery Today. 23:300-314 Journal 2018
10 Hitesh Kumar, Avinash Gothwal, Iliyas Khan, Kartik T Nakhate, Amit Alexander, Ajazuddin, Vineeta Singh, Umesh Gupta* Galactose Anchored Gelatin Nanoparticles for Primaquine Delivery and Improved Pharmacokinetics: A Biodegradable and Safe Approach for Effective Anti-plasmodial Activity Against P. falciparum 3D7 and in vivo Hepatocytes Targeting Molecular Pharmaceutics. 14:3356-3369 Journal 2017
11 Iliyas Khan, Hitesh Kumar, Gaurav Mishra, Avinash Gothwal, Umesh Gupta* Polymeric Nanocarriers: A New Horizon for the Effective Management of Breast Cancer Current Pharmaceutical Design. 23:5315-5326 Journal 2017
12 Seema Upadhyay, Iliyas Khan, Avinash Gothwal, Pravin Pachouri, N. Bhaskar, Umesh D. Gupta, Devendra Singh Chauhan and Umesh Gupta* Conjugated and Entrapped HPMA-PLA Nano-polymeric Micelles Based Dual Delivery of First Line Anti TB Drugs: Improved and Safe Drug Delivery against Sensitive and Resistant Mycobacterium Tuberculosis Pharmaceutical Research. 34:1944-55 Journal 2017
13 Lokesh Gupta, Ashok Kumar Sharma, Avinash Gothwal, Mohammed Shahid Khan, Mahaveer Prasad Khinchi, Arem Qayum, Shashank Kumar Singh, Umesh Gupta* Dendrimer Encapsulated and Conjugated Delivery of Berberine: A Novel Approach Mitigating Toxicity and Improving In Vivo Pharmacokinetics International Journal of Pharmaceutics. 528:88-99 Journal 2017
14 Sonam Choudhary, Lokesh Gupta, Sarita Rani, Kaushal kumar Dave, Umesh Gupta* Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules Frontiers in Pharmacology. 8:1-23 Journal 2017
15 Hitesh Kumar, Gaurav Mishra, Ashok Kumar Sharma, Avinash Gothwal, Prashant Kesharwani, Umesh Gupta* Intranasal Drug Delivery: A Non-Invasive Approach for the Better Delivery of Neurotherapeutics Pharmaceutical Nanotechnology. 5:1-12 Journal 2017
16 Umesh Gupta, Saurabh Sharma, Iliyas Khan, Avinash Gothwal, Ashok K. Sharma, Yuvraj Singh ,Manish K. Chourasia, Vipin Kumar* Enhanced apoptotic and anticancer potential of paclitaxel loaded biodegradable nanoparticles based on chitosan International Journal of Biological Macromolecules. 98:810-819 Journal 2017
17 Jennifer M. Wickens, Hashem O. Alsaab, Prashant Kesharwani, Ketki Bhise, Mohd Cairul Iqbal MohdAmin, Rakesh Kumar Tekade, Umesh Gupta, Arun K. Iyer Recent advances in hyaluronic acid-decorated nanocarriers for targeted cancer therapy Drug Discovery Today. 22:665-680 Journal 2017
18 Sonam Chaudhary, Avinash Gothwal, Iliyas Khan, Shubham Srivastava, Ruchi Malik, Umesh Gupta* Polypropyleneimine and polyamidoamine dendrimer mediated enhanced solubilization of bortezomib: Comparison and evaluation of mehanistic aspects by thermodynamics and molecular simulations Materials Science and Engineering C. 72:611-619 Journal 2017
19 Ashok Kumar Sharma, Avinash Gothwal, Prashant Kesharwani, Hashem Alsaab, Arun K. Iyer, Umesh Gupta* Dendrimer nanoarchitectures for cancer diagnosis and anticancer drug delivery Drug Discovery Today. 22(2):314-326 Journal 2017
20 Iliyas Khan, Avinash Gothwal, Ashok Kumar Sharma, Arem Qayum, Shashank K. Singh, Umesh Gupta* Biodegradable nano-architectural PEGylated approach for the improved stability and anticancer efficacy of Bendamustine International Journal of Biological Macromolecules. 92:1242-1251 Journal 2016
21 Duy Luong, Prashant Kesharwani, Rahul Deshmukh, Mohd Cairul Iqbal Mohd Amin, Umesh Gupta, Khaled Greish, Arun K Iyer PEGylated PAMAM Dendrimers: Enhancing Efficacy and Mitigating Toxicity for Effective Anticancer Drug and Gene Delivery Acta Biomaterilia. 43:14-29 Journal 2016
22 Iliyas Khan, Avinash Gothwal, Ashok Kumar Sharma, Prashant Kesharwani, Lokesh Gupta, Arun Iyer, Umesh Gupta* PLGA nanoparticles and their versatile role in anticancer drug delivery Critical Reviews in Therapeutic Drug Carrier Systems. 33(2):159-193 Journal 2016
23 Pawan Kumar Pandey, Ashok Kumar Sharma, Umesh Gupta* Blood Brain Barrier: An overview on Strategies in Drug Delivery, Realistic In Vitro Modelling and In Vivo Live Tracking Tissue Barriers. 4(1):e1129476-1 to e1129476-14 Journal 2016
24 Avinash Gothwal, Ashok Kumar Sharma, Iliyas Khan, Lokesh Gupta, Umesh Gupta* Dendrimers in combination therapy of cancers Asian Journal of Pharmacy and Pharmacology. 1(2):48-52 Journal 2016
25 Namrata Soni, Keerti Jain, Umesh Gupta, N. K. Jain Controlled delivery of Gemcitabine Hydrochloride using mannosylated poly(propyleneimine) dendrimers Journal of Nanoparticle Research. 17:1-17 Journal 2015
26 Anurag Kumar Singh, Sonam Choudhary, Sarita Rani, Ashok Kumar Sharma, Lokesh Gupta, Umesh Gupta* Dendrimer-drug conjugates in drug delivery and targeting Pharmaceutical Nanotechnology. 3(4):239-260 Journal 2015
27 Avinash Gothwal, Iliyas Khan, Umesh Gupta* Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs Pharmaceutical Research. 33(1):18-39 Journal 2015
28 Avinash Gothwal, Prashant Kesharwani, Umesh Gupta, Iliyas Khan, Mohd Cairul Iqbal Mohd Amin, Sanjeev Banerjee, Arun K. Iyer Dendrimers as an Effective Nanocarrier in Cardiovascular Disease Current Pharmaceutical Design. 21(30):4519-4526 Journal 2015
29 Prashant Kesharwani, Sanjeev Banerjee, Umesh Gupta, Mohd Cairul Iqbal Mohd Amin, Subhash Padhye, Fazlul H. Sarkar, Arun K. Iyer PAMAM dendrimers as promising nanocarriers for RNAi therapeutics Materials Today. 2015;18(10):565–572 Journal 2015
30 Rajeev Sharma, Neeraj K Garg, Rajeev K Tyagi, Umesh Gupta, N K Jain Surface engineered and ligand anchored nanobioconjugate: An effective therapeutic approach for oral insulin delivery in experimental diabetic rats Colloids and Surfaces B: Biointerfaces. 127:172-181 Journal 2015
31 Divya Bhargava Bansal, Dipankar Bhadra, Umesh Gupta, NK Jain PEGylated methotrexate based micellar conjugates for anticancer chemotherapy Asian Journal of Pharmaceutics. 9(1):60 Journal 2015
32 Umesh Gupta Hyper-branched dendrimers in drug delivery and solubilization SOJ Journal of Pharmacy and Pharmaceutical Sciences. 1:3 Journal 2014
33 Keerti Jain, Umesh Gupta, N K Jain Dendronized nanoconjugates of lysine and folate for treatment of cancer Eur J Pharm Biopharm. 87(3):500-509 Journal 2014
34 Udita Agrawal, Neelesh Kumar Mehra, Umesh Gupta, N K Jain Hyperbranched dendritic nano-carriers for topical delivery of dithranol J Drug Target. 21(5):497-506 Journal 2013
35 Keerti Jain, Prashant Kesharwani, Umesh Gupta, N. K. Jain A review of glycosylated carriers for drug delivery Biomaterials. 33(16):4166-4186 Journal 2012
36 Umesh Gupta, N. K. Jain Non-polymeric nano-carriers in HIV/AIDS drug delivery and targeting Advanced Drug Delivery Reviews. 62:478-490 Journal 2010
37 Umesh Gupta, Shailendra Kumar Dhar Dwivedi, Hemant Kumar Bid, Rituraj Konwar and N. K. Jain Ligand anchored dendrimers based nanoconstructs for effective targeting to cancer cells Int. J. Pharmaceutics. 393(1-2):186-197 Journal 2010
38 Keerti Jain, Prashant Kesharwani, Umesh Gupta, N K Jain Dendrimer toxicity: Let's meet the challenge Int. J Pharmaceutics. 394:122-142 Journal 2010
39 Kuldeep K Bansal, Deepak Kakde, Umesh Gupta, N K Jain Development and characterization of triazine based dendrimers for delivery of antitumor agent J Nanosci Nanotech. 10(12):8395-8404 Journal 2010
40 Vijay Mishra, Umesh Gupta, N K Jain Biowaiver: an alternative to in vivo pharmacokinetic bioequivalence studies Pharmazie. 65(3):155-161 Journal 2010
41 Vijay Mishra, Umesh Gupta, N K Jain Influence of different generations of poly (propylene imine) dendrimers on human erythrocytes Pharmazie. 65(12):891-895 Journal 2010
42 Vijay Mishra, Umesh Gupta, N K Jain Surface-engineered dendrimers: a solution for toxicity issues J Biomater Sci Polym Ed. 20(2):141-166 Journal 2009
43 N K Jain, Ramnarayan Prajapati, Abhinav Agarwal, Umesh Gupta, Abhay Asthana Dendrimers-Reflections on host-guest interaction mechanism towards solubility enhancement Asian J Pharmaceutics. 3(3):188-196 Journal 2009
44 Ramnarayan Prajapati, Rakesh Tekade, Umesh Gupta, Virendra Gajbhiye, N. K. Jain Dendimer mediated solubilization, formulation development and in vitro- in vivo assessment of piroxicam Molecular Pharmaceutics. 6(3):940-950 Journal 2009
  • Indo-Belarus Joint Call: Exploration of aptamer Gint4.T based dendrimeric carrier for the brain delivery of anticancer drug temozolomide (2023-2025)
  • DST-SERB (60.9 Lakh): Design, synthesis and characterization of multifunctional platform for targeted tumor phototherapy. (2018-21)
  • DST-SERB (28.54 Lakh): Multifunctional nanotherapeutics for the effective treatment of advanced breast cancer: A dual delivery approach for siRNA and anticancer drug. (2015-18) 
  • DST-Rajasthan (3.06 Lakh): Dendrimer mediated non-invasive delivery of Rifampicin and Imipenem for the effective treatment of pulmonary tuberculosis. (2016-19)
  • UGC-BSR (6 Lakh): Evaluation of PAMAM dendrimers to deliver drugs bypassing blood brain barrier through nasal route. (2014-17)

Organized

  • Four Weeks Induction Program for the Faculty Members of Higher Educational Institutions (HEIs) from 1st May to 26th May 2018 at Central University of Rajasthan under Teaching Learning Centre (TLC).
  • National Conference on "Impact of Molecular Biology on Drug Discovery and Development: Promises and Challenges" at Department of Pharmacy, Central University of Rajasthan from 17th to 18th, February 2015.
  • 1st International Conference on “Novel Frontiers in Pharmaceutical & Health Sciences INNOPHARM-1”. 10-11th Oct. 2015; M.P. Council of Science & Technology, Vigyan Bhawan, Nehru Nagar, Bhopal (M.P.) India.
  • 2nd International Conference on “Bridging Innovations in Pharmaceutical, Medical and Bio Sciences. INNOPHARM-2” 11-12th Feb. 2017; M.P. Council of Science & Technology, Vigyan Bhawan, Nehru Nagar, Bhopal, M.P., India.
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